Vogt P K
Arzneimittelforschung. 1987 Feb;37(2A):243-5.
Proto-onc genes are cellular genes controlling growth and differentiation. Their products form regulatory networks and include growth factors, receptors, signal transducers, amplifiers and nuclear proteins. Proto-onc genes have the potential to induce and maintain the cancerous phenotype of the cell if they are altered in structure or expression through transduction by a retrovirus or through in situ mutations.
原癌基因是控制细胞生长和分化的细胞基因。它们的产物构成调节网络，包括生长因子、受体、信号转导分子、信号放大器和核蛋白。如果原癌基因通过逆转录病毒转导或原位突变而在结构或表达上发生改变，它们就有可能诱导并维持细胞的癌表型。
