Shah D M, Gomez-Sanchez C E, Knuppel R A, Vaughn W K
Am J Perinatol. 1987 Apr;4(2):102-5. doi: 10.1055/s-2007-999749.
Normal pregnancy and pre-eclampsia are associated with water and sodium retention. Therefore various mineralocorticoids have been evaluated in normal and abnormal pregnancies. This study reports the urinary free 19-nor-deoxycorticosterone (19-nor-DOC) and deoxycorticosterone (DOC) levels in normal pregnancy and in patients with pregnancy-induced hypertension. Levels of 19-nor-DOC and DOC were not significantly different between normal patients in the third trimester and women with pregnancy-induced hypertension at a comparable gestational age. The urinary excretion of 19-nor-DOC in pregnancy was noted to be significantly lower than that previously reported in normal male volunteers. There was a positive correlation between 19-nor-DOC excretion and increasing gestational age. These data are compatible with the view that 19-nor-DOC may not play a role in pregnancy-induced hypertension. However, a larger study of primigravid women, with and without, pre-eclampsia is needed to confirm this finding.
正常妊娠和子痫前期与水钠潴留有关。因此，人们对各种盐皮质激素在正常和异常妊娠中的作用进行了评估。本研究报告了正常妊娠和妊娠高血压患者尿游离19-去甲脱氧皮质酮（19-nor-DOC）和脱氧皮质酮（DOC）水平。在孕晚期的正常患者和孕周相当的妊娠高血压女性中，19-nor-DOC和DOC水平无显著差异。妊娠期间19-nor-DOC的尿排泄量明显低于先前正常男性志愿者的报告值。19-nor-DOC排泄量与孕周增加呈正相关。这些数据支持19-nor-DOC可能在妊娠高血压中不起作用的观点。然而，需要对有或无子痫前期的初产妇进行更大规模的研究来证实这一发现。
