轻度妊娠高血压综合征患者血浆及羊水前列环素和血栓素水平的研究
Plasma and amniotic fluid prostacyclin and thromboxane in mild pregnancy-induced hypertension.
作者信息
Brown H L, Klein L, Waitzman M
出版信息
Am J Perinatol. 1987 Apr;4(2):152-4. doi: 10.1055/s-2007-999761.
To study the involvement of 6 keto prostaglandin F1 alpha (6 keto PGF1 alpha) and thromboxane B2 (TxB2) in mild pregnancy-induced hypertension (PIH), we measured amniotic fluid and plasma concentration of these prostanoids by radioimmunoassay in PIH subjects and normotensive pregnant controls. The results suggest no difference in plasma or amniotic fluid 6 keto PGF1 alpha or plasma TxB2 in PIH and control subjects. The concentration of TxB2 (mean +/- SE) in amniotic fluid, however, were 189.5 +/- 27.7 for PIH and 107.4 +/- 9.7 for controls (P less than 0.05). This increase in vasoconstrictor TxB2 over vasodilator 6 keto PGF1 alpha may have implications in the hypertensive vascular response of mild PIH.
为研究6-酮-前列腺素F1α（6-keto PGF1α）和血栓素B2（TxB2）与轻度妊娠高血压综合征（PIH）的关系，我们采用放射免疫分析法测定了PIH患者和血压正常的孕妇对照组羊水和血浆中这些前列腺素的浓度。结果显示，PIH患者与对照组的血浆或羊水6-keto PGF1α及血浆TxB2无差异。然而，PIH患者羊水TxB2浓度（均值±标准误）为189.5±27.7，对照组为107.4±9.7（P<0.05）。血管收缩剂TxB2相对于血管舒张剂6-keto PGF1α的这种升高，可能与轻度PIH的高血压血管反应有关。
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