基于正念的认知疗法：对改变焦虑中与威胁相关的注意偏向的（事件相关）潜力的初步考察。

Mindfulness-Based Cognitive Therapy: A Preliminary Examination of the (Event-Related) Potential for Modifying Threat-Related Attentional Bias in Anxiety.

作者信息

Gupta Resh S, Kujawa Autumn, Fresco David M, Kang Hakmook, Vago David R

机构信息

Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093-0012 USA.

Sam and Rose Stein Institute for Research on Aging, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093-0012 USA.

出版信息

Mindfulness (N Y). 2022;13(7):1719-1732. doi: 10.1007/s12671-022-01910-x. Epub 2022 Jun 1.

DOI:10.1007/s12671-022-01910-x

PMID:35668874

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9159034/

Abstract

OBJECTIVES

Mindfulness-based cognitive therapy (MBCT) can reduce anxiety and depression symptoms in adults with anxiety disorders, and changes in threat-related attentional bias may be a key mechanism driving the intervention's effects on anxiety symptoms. Event-related potentials (ERPs) can illuminate the physiological mechanism through which MBCT targets threat bias and reduces symptoms of anxiety. This preliminary study examined whether P1 ERP threat-related attentional bias markers in anxious adults change from pre- to post-MBCT delivered in-person or virtually (via Zoom) and investigated the relationship between P1 threat-related attentional bias markers and treatment response.

METHODS

Pre- and post-MBCT, participants with moderate to high levels of anxiety ( = 50) completed a dot-probe task with simultaneous EEG recording. Analyses focused on pre- and post-MBCT P1 amplitudes elicited by angry-neutral and happy-neutral face pair cues, probes, and reaction times in the dot-probe task and anxiety and depression symptoms.

RESULTS

Pre- to post-MBCT, there was a significant reduction in P1-Probe amplitudes ( = .23), anxiety ( = .41) and depression ( = .80) symptoms, and reaction times ( = .10). Larger P1-Angry Cue amplitudes, indexing hypervigilance to angry faces, were associated with higher levels of anxiety both pre- and post-MBCT ( = .20). Post-MBCT, anxiety symptoms were lower in the in-person versus virtual group ( = .80).

CONCLUSIONS

MBCT may increase processing efficiency and decreases anxiety and depression symptoms in anxious adults. However, changes in threat bias specifically were generally not supported. Replication with a comparison group is needed to clarify whether changes were MBCT-specific.

CLINICAL TRIALS REGISTRATION

NCT03571386, June 18, 2018.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s12671-022-01910-x.

摘要

目的

基于正念的认知疗法（MBCT）可减轻焦虑症成人的焦虑和抑郁症状，与威胁相关的注意力偏差变化可能是驱动该干预措施对焦虑症状产生影响的关键机制。事件相关电位（ERP）可以阐明MBCT针对威胁偏差并减轻焦虑症状的生理机制。这项初步研究考察了焦虑成人中P1 ERP与威胁相关的注意力偏差指标在面对面或虚拟（通过Zoom）实施MBCT前后是否发生变化，并研究了P1与威胁相关的注意力偏差指标与治疗反应之间的关系。

方法

在MBCT前后，中度至高度焦虑的参与者（n = 50）完成了一项点探测任务，并同时进行脑电图记录。分析重点关注MBCT前后由愤怒-中性和快乐-中性面孔对线索、探测刺激引发的P1波幅，以及点探测任务中的反应时间、焦虑和抑郁症状。

结果

MBCT前后，P1-探测刺激波幅（r = 0.23）、焦虑（r = 0.41）和抑郁（r = 0.80）症状以及反应时间（r = 0.10）均显著降低。更大的P1-愤怒线索波幅表明对愤怒面孔过度警觉，在MBCT前后均与更高水平的焦虑相关（r = 0.20）。MBCT后，面对面组的焦虑症状低于虚拟组（r = 0.80）。