Pirkkalainen Hertta, Talvio Isto, Kujala-Wirth Minna, Soveri Timo, Orro Toomas
Department of Production Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Paroninkuja 20, Saarentaus, 04920 Finland.
Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Science, Kreutzwaldi 62, Tartu, 51006 Estonia.
Vet Anim Sci. 2022 May 28;17:100253. doi: 10.1016/j.vas.2022.100253. eCollection 2022 Sep.
Hoof disorders cause lameness and welfare problems for dairy cattle. Acute phase proteins, including serum amyloid A and haptoglobin, with increased rectal temperature and interleukin-6 concentrations, are markers of acute phase response. This study assessed the inflammatory response of cows with either sole ulcer, white line disease or digital dermatitis compared to healthy cows. Another aim was to monitor the inflammatory response changes over time after diagnosis (at hoof trimming, seven and 14 days later) in cows with different hoof disorders. Serum amyloid A concentration in cows with sole ulcer was significantly higher compared with the control group (cows with no hoof lesions) within the two-week study period. Interleukin-6 and rectal temperature declined from day zero to day seven in the sole ulcer group. These results suggest that sole ulcers initiate a long lasting systemic inflammatory response in dairy cows.
蹄部疾病会给奶牛带来跛行和福利问题。急性期蛋白，包括血清淀粉样蛋白A和触珠蛋白，以及直肠温度和白细胞介素-6浓度升高，是急性期反应的标志物。本研究评估了患有蹄底溃疡、白线病或趾间皮炎的奶牛与健康奶牛相比的炎症反应。另一个目的是监测不同蹄部疾病的奶牛在诊断后（在蹄修整时、7天和14天后）随时间的炎症反应变化。在为期两周的研究期间，患有蹄底溃疡的奶牛血清淀粉样蛋白A浓度与对照组（无蹄部病变的奶牛）相比显著更高。蹄底溃疡组的白细胞介素-6和直肠温度从第0天到第7天有所下降。这些结果表明，蹄底溃疡会引发奶牛长期的全身炎症反应。
