Wells J R, Gernon W H
Arch Otolaryngol Head Neck Surg. 1987 Jun;113(6):644-6. doi: 10.1001/archotol.1987.01860060070017.
We investigated the effects of 2-cyano-butyl-acrylate (Histoacryl) on the ossicles of 11 of 12 adult guinea pigs. A small amount of the adhesive, placed precisely between the incus and its bony fossa in each middle ear, fixed the ossicles. Light microscopic investigation of the ears of animals killed at 3, 6, 9, and 12 months after surgery showed a bony union of the ossicle to its surrounding niche in 11 of 12 operated-on ears. Negligible inflammatory reaction was seen in areas of the middle ear not in contact with the adhesive. These observations suggest that 2-cyano-butyl-acrylate may be used to achieve a durable bony union in ossiculoplastic surgery with minimal side effects in the middle ear.
我们研究了2-氰基丙烯酸丁酯（组织黏合剂）对12只成年豚鼠中11只听小骨的影响。在每只中耳的砧骨与其骨窝之间精确放置少量粘合剂，从而固定听小骨。对术后3个月、6个月、9个月和12个月处死的动物耳朵进行光学显微镜检查，结果显示，在12只接受手术的耳朵中，有11只的听小骨与其周围龛形成了骨性结合。在中耳未与粘合剂接触的区域，观察到的炎症反应可忽略不计。这些观察结果表明，2-氰基丙烯酸丁酯可用于听骨成形手术中，以实现持久的骨性结合，同时使中耳的副作用最小化。
