Heumann H, Steinbach E
Arch Otolaryngol. 1980 Dec;106(12):734-6. doi: 10.1001/archotol.1980.00790360012004.
This study investigated the effects of enbucrilate (Histoacryl) on the middle ear. Small amounts of the adhesive were used in 81 middle-ear operations performed on 50 rabbits. Light microscopic investigation of these ears 1, 2, and 3 months after surgery showed bone necrosis and a granulation tissue reaction surrounded by foreign-body giant cells. Inner-ear changes were observed in a third of the cases. Therefore, enbucrilate should only be used with extreme care and in minute quantities and never near the labyrinthine capsule.
本研究调查了氰基丙烯酸正丁酯（组织黏合剂）对中耳的影响。在对50只兔子进行的81例中耳手术中使用了少量这种黏合剂。术后1、2和3个月对这些耳朵进行光镜检查，结果显示有骨坏死以及由异物巨细胞包围的肉芽组织反应。三分之一的病例观察到内耳有变化。因此，使用氰基丙烯酸正丁酯时应极其谨慎，且用量要极小，绝不能靠近迷路囊。
