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注射CHIR-99021可促进鹅胚毛囊发育，调节Wnt信号通路和转录组（）。

Injection of CHIR-99021 Promotes Feather Follicle Development Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos ().

作者信息

Feng Ziqiang, Gong Haizhou, Fu Jinhong, Xu Xiaohui, Song Yupu, Yan Xiaomin, Mabrouk Ichraf, Zhou Yuxuan, Wang Yudong, Fu Xianou, Sui Yujian, Liu Tuoya, Li Chuanghang, Liu Zebei, Tian Xu, Sun Le, Guo Keying, Sun Yongfeng, Hu Jingtao

机构信息

College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.

Key Laboratory of Animal Production, Product Quality and Security (Jilin Agricultural University), Ministry of Education, Changchun, China.

出版信息

Front Physiol. 2022 May 20;13:858274. doi: 10.3389/fphys.2022.858274. eCollection 2022.

DOI:10.3389/fphys.2022.858274
PMID:35669574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9164139/
Abstract

Feather performs important physiological functions in birds, and it is also one of the economic productions in goose farming. Understanding and modulating feather follicle development during embryogenesis are essential for bird biology and the poultry industry. CHIR-99021 is a potent Wnt/β-catenin signaling pathway activator associated with feather follicle development. In this study, goose embryos () received an in ovo injection of CHIR-9902, which was conducted at the beginning of feather follicle development (E9). The results showed that feather growth and feather follicle development were promoted. The Wnt signaling pathway was activated by the inhibition of GSK-3β. Transcriptomic analyses showed that the transcription changes were related to translation, metabolism, energy transport, and stress in dorsal tissue of embryos that received CHIR-99021, which might be to adapt and coordinate the promoting effects of CHIR-99021 on feather follicle development. This study suggests that injection of CHIR-99021 is a potential strategy to improve feather follicle development and feather-related traits for goose farming and provides profiling of the Wnt signaling pathway and transcriptome in dorsal tissue of goose embryos for further understanding of feather follicle development.

摘要

羽毛在鸟类中执行重要的生理功能，并且它也是养鹅业的经济产品之一。了解和调控胚胎发育期间的毛囊发育对于鸟类生物学和家禽业至关重要。CHIR-99021是一种与毛囊发育相关的有效的Wnt/β-连环蛋白信号通路激活剂。在本研究中，鹅胚胎在毛囊发育开始时（E9）接受了CHIR-9902的卵内注射。结果表明，羽毛生长和毛囊发育得到促进。Wnt信号通路通过抑制GSK-3β而被激活。转录组分析表明，接受CHIR-99021的胚胎背部组织中的转录变化与翻译、代谢、能量运输和应激有关，这可能是为了适应和协调CHIR-99021对毛囊发育的促进作用。本研究表明，注射CHIR-99021是改善养鹅业毛囊发育和羽毛相关性状的一种潜在策略，并提供了鹅胚胎背部组织中Wnt信号通路和转录组的概况，以进一步了解毛囊发育。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd83/9164139/87bc3088c346/fphys-13-858274-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd83/9164139/5945d03c9390/fphys-13-858274-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd83/9164139/0b012559b951/fphys-13-858274-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd83/9164139/87bc3088c346/fphys-13-858274-g008.jpg

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本文引用的文献

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GSK3ß inhibitor CHIR 99021 modulates cerebral organoid development through dose-dependent regulation of apoptosis, proliferation, differentiation and migration.GSK3β 抑制剂 CHIR99021 通过剂量依赖性调节细胞凋亡、增殖、分化和迁移来调节类器官的发育。
PLoS One. 2021 May 5;16(5):e0251173. doi: 10.1371/journal.pone.0251173. eCollection 2021.
2
HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells .含小分子抑制剂 SB431542 和 CHIR99021 以及生长因子 PDGF-AA 的 HaCaT 条件培养基可防止真皮乳头细胞去分化。
Mol Med Rep. 2021 May;23(5). doi: 10.3892/mmr.2021.11965. Epub 2021 Mar 24.
3
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Whole-genome resequencing reveals aberrant autosomal SNPs affect chicken feathering rate.
全基因组重测序揭示异常常染色体单核苷酸多态性影响鸡的羽毛生长速度。
Anim Biotechnol. 2022 Oct;33(5):884-896. doi: 10.1080/10495398.2020.1846545. Epub 2020 Dec 21.
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Structural Heterogeneities of the Ribosome: New Frontiers and Opportunities for Cryo-EM.核糖体的结构异质性：低温电子显微镜的新前沿和机遇。
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