Hsu Chiu-Hao, Chou Sheng-Chieh, Kuo Lu-Ting, Huang Sheng-Jean, Yang Shih-Hung, Lai Dar-Ming, Huang Abel Po-Hao
Department of Surgery, National Taiwan University Hospital Hsin-Chu Branch, Biomedical Park Hospital, Hsin-Chu, Taiwan.
Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Front Neurol. 2022 May 20;13:817386. doi: 10.3389/fneur.2022.817386. eCollection 2022.
Intracerebral hemorrhage (ICH) is a life-threatening disease with a global health burden. Traditional craniotomy has neither improved functional outcomes nor reduced mortality. Minimally invasive neurosurgery (MIN) holds promise for reducing mortality and improving functional outcomes. To evaluate the feasibility of MIN for ICH, a retrospective analysis of patients with ICH undergoing endoscopic-assisted evacuation was performed. From 2012 to 2018, a total of 391 patients who underwent ICH evacuation and 76 patients who received early (<8 h) MIN were included. The rebleeding, mortality, and morbidity rates were 3.9, 7.9, and 3.9%, respectively, 1 month after surgery. At 6 months, the median [interquartile range (IQR)] Glasgow Coma Scale score was 12 (4.75) [preoperative: 10 (4)], the median (IQR) Extended Glasgow Outcome Scale score was 3 (1), and the median (IQR) Modified Rankin Scale score was 4 (1). The results suggested that early (<8 h) endoscope-assisted ICH evacuation is safe and effective for selected patients with ICH. The rebleeding, morbidity, and mortality rates of MIN in this study are lower than those of traditional craniotomy reported in previous studies. However, the management of intraoperative bleeding and hard clots is critical for performing endoscopic evacuation. With this retrospective analysis of MIN cases, we hope to promote the specialization of ICH surgery in the field of MIN.
脑出血(ICH)是一种对全球健康构成负担的危及生命的疾病。传统开颅手术既未改善功能结局,也未降低死亡率。微创神经外科手术(MIN)有望降低死亡率并改善功能结局。为评估MIN治疗ICH的可行性,对接受内镜辅助血肿清除术的ICH患者进行了回顾性分析。2012年至2018年,共纳入391例行ICH血肿清除术的患者和76例接受早期(<8小时)MIN治疗的患者。术后1个月,再出血率、死亡率和发病率分别为3.9%、7.9%和3.9%。6个月时,格拉斯哥昏迷量表评分中位数[四分位间距(IQR)]为12(4.75)[术前:10(4)],扩展格拉斯哥预后量表评分中位数(IQR)为3(1),改良Rankin量表评分中位数(IQR)为4(1)。结果表明,早期(<8小时)内镜辅助ICH血肿清除术对部分ICH患者安全有效。本研究中MIN的再出血率、发病率和死亡率低于既往研究报道的传统开颅手术。然而,术中出血和硬血凝块的处理对于进行内镜下血肿清除至关重要。通过对MIN病例的回顾性分析,我们希望推动MIN领域ICH手术的专业化。