Hannah Theodore C, Kellner Rebecca, Kellner Christopher P
Department of Neurosurgery, Icahn School of Medicine at Mt Sinai, New York, NY 10029, USA.
Diagnostics (Basel). 2021 Mar 23;11(3):576. doi: 10.3390/diagnostics11030576.
Intracerebral hemorrhage (ICH) continues to have high morbidity and mortality. Improving ICH outcomes likely requires rapid removal of blood from the parenchyma and restraining edema formation while also limiting further neuronal damage due to the surgical intervention. Minimally invasive surgery (MIS) approaches promise to provide these benefits and have become alluring options for management of ICH. This review describes six MIS techniques for ICH evacuation including craniopuncture, stereotactic aspiration with thrombolysis, endoport-mediated evacuation, endoscope-assisted evacuation, adjunctive aspiration devices, and the surgiscope. The efficacy of each modality is discussed based on current literature. The largest clinical trials have yet to demonstrate definitive effects of MIS intervention on mortality and functional outcomes for ICH. Thus, there is a significant need for further innovation for ICH treatment. Multiple ongoing trials promise to better clarify the potential of the newer, non-thrombolytic MIS techniques.
脑出血(ICH)的发病率和死亡率仍然很高。改善脑出血的预后可能需要迅速清除脑实质内的血液,抑制水肿形成,同时还要限制手术干预导致的进一步神经元损伤。微创手术(MIS)方法有望带来这些益处,已成为脑出血治疗的诱人选择。本综述描述了六种用于脑出血清除的微创手术技术,包括颅骨穿刺、立体定向溶栓抽吸、端口介导的清除、内镜辅助清除、辅助抽吸装置和手术内镜。根据现有文献讨论了每种方式的疗效。最大规模的临床试验尚未证明微创手术干预对脑出血死亡率和功能预后有确切影响。因此,脑出血治疗急需进一步创新。多项正在进行的试验有望更好地阐明新型非溶栓微创手术技术的潜力。