Asakage Takahiro
Department of Head and Neck Surgery, Tokyo Medical and Dental University Hospital.
No Shinkei Geka. 2022 May;50(3):578-585. doi: 10.11477/mf.1436204590.
Skull base surgery for malignant skull base disease is one of the most difficult surgeries. The success of the surgery depends on the harmonization of the excellent skills of the three departments: neurosurgery, otorhinolaryngology/head and neck surgery, and plastic surgery. In addition, it is necessary to perform complete resection, that is, resection in which the malignant tumor is removed along with some surrounding healthy tissue. It is known that there is a statistically significant difference between negative and positive resection margins. In the event of a positive resection margin, chemoradiation with high-dose cisplatin is standard for the most common squamous cell carcinomas.
针对恶性颅底疾病的颅底手术是最具难度的手术之一。手术的成功取决于神经外科、耳鼻咽喉/头颈外科和整形外科这三个科室精湛技术的协同配合。此外，必须进行完整切除，即连同一些周围健康组织一并切除恶性肿瘤。据了解，阴性和阳性切缘之间在统计学上存在显著差异。如果切缘为阳性，对于最常见的鳞状细胞癌，以高剂量顺铂进行放化疗是标准治疗方法。
