School of Nursing, Lanzhou University, Lanzhou, Gansu, China.
West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Expert Rev Respir Med. 2022 May;16(5):567-574. doi: 10.1080/17476348.2022.2086123. Epub 2022 Jun 17.
Oropharyngeal dysphagia (OD) in chronic obstructive pulmonary disease (COPD) patients seriously influence the long-term prognosis of COPD patients. The aim of this study was to assess the prevalence and risk factors of OD in patients with COPD through a systematic review and meta-analysis of observational studies.
We identified all observational studies on the prevalence of OD in COPD patients by searching PubMed, Embase, the Cochrane Library, Web of Science, Cumulative Index to Nursing and Allied Health Literature (CINAHL), China National Knowledge Infrastructure (CNKI), the China Biomedical Literature Service System (CBM), the Wanfang Database, and the WeiPu (VIP) databases from database establishment to 1 December 2020.
Results of the meta-analysis showed that the prevalence of OD in COPD patients was 32.7% (95%CI=30.1, 35.4, I2=91.5%). Dyspnea, gastroesophageal reflux disease(GERD), xerostomia, sputum bacteria, poor physical capacity, poor quality of life, and high CRP level are the risk factors for OD in COPD patients.
: The prevalence of OD in COPD patients is high. There were some differences in OD among COPD patients with different sex, ages, continents, evaluation methods, patient source and COPD exacerbation.
慢性阻塞性肺疾病（COPD）患者的口咽吞咽困难（OD）严重影响 COPD 患者的长期预后。本研究旨在通过对 COPD 患者 OD 的观察性研究进行系统评价和荟萃分析，评估 OD 在 COPD 患者中的患病率和危险因素。
我们通过检索 PubMed、Embase、Cochrane 图书馆、Web of Science、Cumulative Index to Nursing and Allied Health Literature（CINAHL）、中国知网（CNKI）、中国生物医学文献服务系统（CBM）、万方数据库和维普（VIP）数据库，从数据库建立到 2020 年 12 月 1 日，确定了所有关于 COPD 患者 OD 患病率的观察性研究。
荟萃分析结果显示，COPD 患者 OD 的患病率为 32.7%（95%CI=30.1, 35.4，I2=91.5%）。呼吸困难、胃食管反流病（GERD）、口干、痰液细菌、身体机能差、生活质量差和高 C 反应蛋白水平是 COPD 患者发生 OD 的危险因素。
COPD 患者的 OD 患病率较高。不同性别、年龄、大洲、评估方法、患者来源和 COPD 加重的 COPD 患者的 OD 存在一定差异。
