Ye Junrong, Pan Yuanxin, Zhou Tingwei, Liu Fei, Wei Yanheng, Chen Jiao, Wang Wen, Zheng Xueyu, Liu Dingjie, Wu Shengwei, Li Zezhi, Guo Jianxiong, Xiao Aixiang
The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China.
Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China.
Front Psychiatry. 2024 Oct 8;15:1482951. doi: 10.3389/fpsyt.2024.1482951. eCollection 2024.
To investigate the influencing factors of dysphagia in Alzheimer's disease (AD) patients.
The study evaluated the demographic characteristics, nutritional status, social functioning, and swallowing dysfunction of 109 hospitalized AD patients.
The sample include 65.1% of female patients, mainly concentrate in >70 years old (72.5%). The illness duration is mainly 0~5 years (62.4%). After adjusting for confounding factors such as gender, poor lifestyle habits, illness duration, marital status, route to admission, concomitant medical illness, nutritional status, and social functioning, we find that the swallowing function in patients with AD is related to route to admission and concomitant medical illness (mainly includes: circulatory disease and respiratory disease). Age ≥90 years old and more concomitant medical illness contribute to a lower swallowing dysfunction score in patients with AD (<0.05).
Age and concomitant medical illness are the important influencing factors in swallowing dysfunction in patients with AD. Therefore, we believe that future research should focus on the treatment and care of patients with medical conditions in order to enhance the swallowing function in patients with AD.
探讨阿尔茨海默病（AD）患者吞咽困难的影响因素。
本研究评估了109例住院AD患者的人口统计学特征、营养状况、社会功能和吞咽功能障碍。
样本中女性患者占65.1%，主要集中在70岁以上（72.5%）。病程主要为0至5年（62.4%）。在调整了性别、不良生活习惯、病程、婚姻状况、入院途径、合并内科疾病、营养状况和社会功能等混杂因素后，我们发现AD患者的吞咽功能与入院途径和合并内科疾病（主要包括：循环系统疾病和呼吸系统疾病）有关。年龄≥90岁且合并内科疾病较多会导致AD患者吞咽功能障碍评分较低（<0.05）。
年龄和合并内科疾病是AD患者吞咽功能障碍的重要影响因素。因此，我们认为未来的研究应聚焦于患有内科疾病患者的治疗和护理，以提高AD患者的吞咽功能。
