Laboratory of Biology and Health, Department of Life Sciences, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Laboratory of Pathological Anatomy and Cytology, El Idrissi Public Hospital, Kenitra, Morocco.
Curr Drug Saf. 2023;18(4):504-510. doi: 10.2174/1574886317666220606153524.
In traditional herbal medicine, the Coriandrum sativum (CS) seeds are widely used to prevent and/or treat several diseases. Despite this, research into studying their toxicity is very limited.
This study aims at studying the acute and subacute toxicity of aqueous extract of coriander seeds (AECS) in Wistar rats.
For acute toxicity, five dose levels (500, 1000, 2000, 3000, and 5000 mgkg) were tested per single oral administration. Subacute toxicity for 28 days was achieved by daily oral administration of AECS at doses of 1000, 2000, and 3000 mgkg.
No deaths or signs were recorded or observed in rats in the five groups and the control group was after 14 days of acute toxicity study. The results of subacute toxicity revealed that the administration of AECS caused a significant difference in the body weight of rats at doses of 2000 and 3000mgkg, and in the development of movement disturbances, hypoactivity, drowsiness, weakness, and diarrhea, while histopathological examination showed vascular congestion and inflammation of the kidneys as well as hepatic necrosis. The haematological profile showed a significant increase in the number of red and white blood cells, haemoglobin, haematocrit, and a nonsignificant decrease is noticed in neutrophils at a dose of 3000 mgkg.
AECS should be used with caution as it has caused some signs of toxicity and may affect the liver and kidneys if doses are repeated. However, further studies are needed to verify and clarify the toxic aspect of Coriandrum sativum L. seeds.
在传统草药医学中，芫荽（CS）种子被广泛用于预防和/或治疗多种疾病。尽管如此，研究其毒性的研究非常有限。
本研究旨在研究芫荽籽水提物（AECS）在 Wistar 大鼠中的急性和亚急性毒性。
急性毒性试验，单次口服 5 个剂量水平（500、1000、2000、3000 和 5000mgkg）。亚急性毒性试验通过每日口服 AECS，剂量分别为 1000、2000 和 3000mgkg，持续 28 天。
在急性毒性研究的第 14 天，五组和对照组的大鼠均未出现死亡或体征。亚急性毒性试验结果表明，AECS 给药导致 2000 和 3000mgkg 剂量的大鼠体重显著差异，运动障碍、活动减少、嗜睡、虚弱和腹泻的发展，组织病理学检查显示肾脏和肝脏的血管充血和坏死。血液学特征显示，在 3000mgkg 剂量下，红细胞和白细胞、血红蛋白、血细胞比容的数量显著增加，中性粒细胞数量略有下降。
AECS 应谨慎使用，因为它已经引起了一些毒性迹象，如果重复使用可能会影响肝脏和肾脏。然而，需要进一步的研究来验证和澄清芫荽种子的毒性方面。
