Ray Suman Kumar, Mukherjee Sukhes
Independent Researcher, Bhopal, Madhya Pradesh, India.
Department of Biochemistry, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh-462020, India.
Infect Disord Drug Targets. 2023;23(1):e060622205636. doi: 10.2174/1871526522666220606092243.
SARS-CoV-2 Delta variant, also known as lineage B.1.617.2, is a variant of lineage B.1.617 of SARS-CoV-2, the virus that causes COVID-19. The B.1.617.2 variant was first discovered in India in December 2020, and by mid-April 2021, it had become the most often reported variant. On May 31, 2021, the World Health Organization (WHO) designated it as the Delta variation. Delta is 40-60% more transmissible than Alpha and nearly twice as transmissible as the original Wuhan strain of SARSCoV- 2, according to data. According to some evidence, the Delta variation may cause more severe illness in unprotected people than prior variants. A rapid increase in instances of this variation has been observed in the United Kingdom, which has been linked to travel from India and community transmission. WHO reports that the Delta version of COVID-19 has already been found in different countries throughout the world. According to the available information, the Delta variant appears to increase transmissibility, secondary attack rate, hospitalization risk, and immune escape. Due to the lack of data, the possible effects of the Delta variation on vaccination and treatment effectiveness remain unknown. However, neutralization efficiency in vaccinated people and resistance to monoclonal antibody therapy of the Delta variant have been documented in recent investigations.
严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的德尔塔变种,也称为B.1.617.2谱系,是导致新冠肺炎的SARS-CoV-2病毒B.1.617谱系的一个变种。B.1.617.2变种于2020年12月在印度首次发现,到2021年4月中旬,它已成为报告频率最高的变种。2021年5月31日,世界卫生组织(WHO)将其指定为德尔塔变种。数据显示,德尔塔变种的传播性比阿尔法变种高40%-60%,几乎是原始的武汉株SARS-CoV-2传播性的两倍。有证据表明,德尔塔变种可能会使未受保护的人群比之前的变种更容易患上更严重的疾病。在英国观察到该变种病例迅速增加,这与来自印度的旅行和社区传播有关。WHO报告称,新冠肺炎的德尔塔变种已在世界各国被发现。根据现有信息,德尔塔变种似乎会增加传播性、继发感染率、住院风险和免疫逃逸。由于缺乏数据,德尔塔变种对疫苗接种和治疗效果的可能影响仍不清楚。然而,最近的调查记录了接种疫苗人群对德尔塔变种的中和效率以及该变种对单克隆抗体疗法的抗性。