Waasdorp M
Ned Tijdschr Tandheelkd. 2022 Jun;129(6):275-278. doi: 10.5177/ntvt.2022.06.21113.
Already for centuries people speculate about the healing power of saliva. Reports in both old and modern literature attribute miraculous healing power, as well as deadly infections to saliva. Fact is, oral wounds heal faster as compared to skin wounds, despite the presence of millions of microbes in the oral cavity. In this paper we aim to summarize the role of saliva in wound healing. Saliva contains numerous peptides, cytokines and growth factors that contribute to wound healing by stimulating blood coagulation, cell migration and proliferation. Moreover, keeping the oral microbiome in check is an important feature of saliva and prerequisite for fast and scarless wound healing. Histatins are small peptides in saliva that carry both wound healing and antimicrobial properties and are considered as potential wound healing therapeutics.
几个世纪以来，人们一直在猜测唾液的治愈能力。古代和现代文献中的报道都将神奇的治愈能力以及致命感染归因于唾液。事实上，尽管口腔中存在数以百万计的微生物，但口腔伤口比皮肤伤口愈合得更快。在本文中，我们旨在总结唾液在伤口愈合中的作用。唾液含有多种肽、细胞因子和生长因子，它们通过刺激血液凝固、细胞迁移和增殖来促进伤口愈合。此外，控制口腔微生物群是唾液的一个重要特征，也是伤口快速无瘢痕愈合的先决条件。组蛋白是唾液中的小肽，具有伤口愈合和抗菌特性，被认为是潜在的伤口愈合治疗剂。
