Department of Cardiopulmonary Bypass, Lanzhou University Second Hospital, Lanzhou, China.
Department of Orthopaedic Surgery, Lanzhou University Second Hospital, Lanzhou, China.
J Tissue Viability. 2021 May;30(2):190-195. doi: 10.1016/j.jtv.2021.01.005. Epub 2021 Jan 20.
Wound healing is a complex and important physiological process that maintains the integrity of skin after various injuries. Abnormal wound healing, especially of chronic wounds, impairs normal physical function. Therefore, the search for effective and safe healing agents is one of the main concerns. Histatins are histidine-rich low molecular weight peptides that are expressed in the saliva of both humans and higher primates. Histatins have two main biological effects, cell stimulation and bacteria killing, with the former playing an important role in wound healing by promoting epithelial cell and fibroblast migration and angiogenesis and enhancing the re-epithelialization of the wounded area. Because of these biological effects, histatins have been shown to be promising agents of improved wound healing. Histatins are categorized into many subtypes, of which histatin 1 and its hydrolysates are the most effective in promoting wound healing. This review addresses the bioactivity of histatins in wound healing, such as their stimulatory effects on epithelial cells and fibroblasts, and elucidates the possible mechanisms by which histatin subtypes induce their biological effects.
创伤愈合是一个复杂而重要的生理过程，它可以维持皮肤在受到各种损伤后的完整性。异常的创伤愈合，特别是慢性创伤愈合，会损害正常的身体功能。因此，寻找有效和安全的愈合剂是主要关注点之一。Histatins 是富含组氨酸的低分子量肽，在人类和高等灵长类动物的唾液中表达。Histatins 具有两种主要的生物学效应，细胞刺激和杀菌作用，前者通过促进上皮细胞和成纤维细胞迁移、血管生成以及增强受伤区域的再上皮化，在创伤愈合中起着重要作用。由于这些生物学效应，Histatins 已被证明是改善创伤愈合的有前途的药物。Histatins 可分为许多亚型，其中 Histatin 1 及其水解产物在促进创伤愈合方面最有效。本文综述了 Histatins 在创伤愈合中的生物活性，如其对上皮细胞和成纤维细胞的刺激作用，并阐明了 Histatin 亚型诱导其生物学效应的可能机制。
