Department of Chemistry, National Chung Hsing University, No. 145, Xingda Road, Taichung 402, Taiwan.
Institute of Biomedical Science, National Chung-Hsing University, No. 145, Xingda Road, Taichung 402, Taiwan.
J Mater Chem B. 2022 Jun 29;10(25):4759-4770. doi: 10.1039/d2tb00344a.
Psoriasis is a chronic inflammatory skin disease that can significantly impact the quality of human life. Various drug treatments are available; however, due to their long-term severe side effects the usage of these drugs is limited. Photodynamic therapy (PDT) has been clinically approved for skin diseases due to its non-invasive nature. We present novel NNO-tridentate vanadium(IV) complexes used in PDT for anti-inflammatory effects in an imiquimod-induced psoriasis-like skin disease mouse model. The vanadium(IV) complexes (1-4) were synthesized using the NNO-tridentate ligand with a benzo[]dipyrido[3,2-;2',3'-]phenazine (dppn) moiety, and were characterized by UV/Visible spectroscopy, EPR spectroscopy, NMR (H, and C) spectroscopy, electrospray ionization mass (ESI-MS) spectrometry and cyclic voltammetry (CV) studies. The photocytotoxicity of vanadium(IV) complexes (1-4) was low under dark conditions and complex (4) showed remarkable photocytotoxicity under blue light (430 nm, 8 W cm, 30 min) irradiation. Moreover, [VO(-butylL)(dppn)] (4)-mediated PDT down-regulated inflammatory cytokines IL-17A and IL-22 in the psoriasis-like mouse model, which could evidence the significant relieving of the psoriatic-like symptoms in the mouse model. Overall, these results suggested that [VO(-butylL)(dppn)] (4) could be a potential candidate for the treatment of psoriasis both and .
银屑病是一种慢性炎症性皮肤病，会严重影响人类的生活质量。有多种药物治疗方法，但由于其长期严重的副作用，这些药物的使用受到限制。光动力疗法（PDT）因其非侵入性而在皮肤病的临床治疗中得到认可。我们提出了在 PDT 中使用的新型 NNO-三齿钒（IV）配合物，用于在咪喹莫特诱导的银屑病样皮肤病小鼠模型中发挥抗炎作用。钒（IV）配合物（1-4）是使用 NNO-三齿配体与苯并[]二吡啶并[3,2-; 2',3'-]吩嗪（dppn）部分合成的，并通过紫外/可见光谱、电子顺磁共振（EPR）光谱、核磁共振（H 和 C）光谱、电喷雾电离质谱（ESI-MS）光谱和循环伏安法（CV）研究进行了表征。在黑暗条件下，钒（IV）配合物（1-4）的光细胞毒性较低，而配合物（4）在蓝光（430nm，8Wcm，30min）照射下显示出显著的光细胞毒性。此外，[VO（-丁基 L）（dppn）]（4）介导的 PDT 下调了银屑病样小鼠模型中的炎症细胞因子 IL-17A 和 IL-22，这可以证明小鼠模型中银屑病样症状得到了显著缓解。总的来说，这些结果表明，[VO（-丁基 L）（dppn）]（4）可能是治疗银屑病的潜在候选药物。
