Department of Clinical and Experimental Pathology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Laboratory of RNA Biochemistry, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 6, 14195 Berlin, Germany.
Int J Mol Sci. 2022 Aug 30;23(17):9845. doi: 10.3390/ijms23179845.
Psoriasis (PS) is an immune-mediated skin disease with substantial negative effects on patient quality of life. Despite significant progress in the development of novel treatment options over the past few decades, a high percentage of patients with psoriasis remain undertreated and require new medications with superior long-term efficacy and safety. One of the most promising treatment options against psoriatic lesions is a form of phototherapy known as photodynamic therapy (PDT), which involves either the systemic or local application of a cell-targeting photosensitizing compound, followed by selective illumination of the lesion with visible light. However, the effectiveness of clinically incorporated photosensitizers in psoriasis treatment is limited, and adverse effects such as pain or burning sensations are frequently reported. In this study, we performed a literature review and attempted to provide a pooled estimate of the efficacy and short-term safety of targeted PDT in the treatment of psoriasis. Despite some encouraging results, PDT remains clinically underutilized. This highlights the need for further studies that will aim to evaluate the efficacy of a wider spectrum of photosensitizers and the potential of nanotechnology in psoriasis treatment.
银屑病（PS）是一种免疫介导的皮肤疾病，对患者的生活质量有重大负面影响。尽管在过去几十年中，新型治疗选择的发展取得了重大进展，但仍有很大比例的银屑病患者治疗不足，需要新的药物，具有更好的长期疗效和安全性。针对银屑病病变最有前途的治疗选择之一是一种称为光动力疗法（PDT）的光疗形式，它包括全身或局部应用靶向细胞的光敏化合物，然后用可见光选择性地照射病变。然而，临床上使用的光敏剂在银屑病治疗中的有效性是有限的，并且经常报告疼痛或烧灼感等不良反应。在本研究中，我们进行了文献回顾，并试图对靶向 PDT 治疗银屑病的疗效和短期安全性进行汇总估计。尽管取得了一些令人鼓舞的结果，但 PDT 在临床上仍未得到充分利用。这凸显了需要进一步研究，旨在评估更广泛的光敏剂的疗效以及纳米技术在银屑病治疗中的潜力。
