急性肝性卟啉病复发期与缓解期的安替比林代谢
Antipyrine metabolism in acute hepatic porphyria in relapse and remission.
作者信息
Birnie G G, McColl K E, Thompson G G, Moore M R, Goldberg A, Brodie M J
出版信息
Br J Clin Pharmacol. 1987 Mar;23(3):358-61. doi: 10.1111/j.1365-2125.1987.tb03059.x.
Antipyrine kinetics following a single oral dose were obtained in porphyric patients in attack and in remission and in controls. The clearance of antipyrine was significantly lower during an acute porphyric attack (median: 0.34 ml min-1 kg-1; range: 0.1-0.71, P less than 0.05) than in patients in remission (median: 0.53 ml min-1 kg-1; range: 0.28-0.87) or controls (median: 0.52 ml min-1 kg-1; range: 0.32-0.93). There was a significant negative correlation between weight-adjusted antipyrine clearance and the urinary excretion of the porphyrin precursors, delta-aminolaevulinic acid (r = 0.86, P less than 0.001) and porphobilinogen (r = 0.82, P less than 0.002). These data suggest that the more severe the porphyric attack, the greater the impairment of hepatic monooxygenase activity.
在急性发作期和缓解期的卟啉症患者以及对照组中，获取了单次口服安替比林后的动力学数据。在急性卟啉症发作期间，安替比林的清除率（中位数：0.34 ml min⁻¹ kg⁻¹；范围：0.1 - 0.71，P < 0.05）显著低于缓解期患者（中位数：0.53 ml min⁻¹ kg⁻¹；范围：0.28 - 0.87）或对照组（中位数：0.52 ml min⁻¹ kg⁻¹；范围：0.32 - 0.93）。体重校正后的安替比林清除率与卟啉前体δ-氨基乙酰丙酸的尿排泄量（r = 0.86，P < 0.001）和胆色素原（r = 0.82，P < 0.002）之间存在显著负相关。这些数据表明，卟啉症发作越严重，肝单加氧酶活性的损害就越大。
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