Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Dermatol Online J. 2022 Mar 15;28(2). doi: 10.5070/D328257399.
Immune-related adverse events (irAEs) are common in patients receiving immune checkpoint inhibitors for metastatic melanoma and other advanced malignancies. Cutaneous, gastrointestinal, and endocrine (thyroid) irAEs are most prevalent, whereas neurologic irAEs are rare. We present a 73-year-old man with dementia and metastatic melanoma who developed immunotherapy-associated encephalitis and subsequently, interstitial granulomatous dermatitis with nivolumab/ipilimumab. High-dose corticosteroids successfully treated both conditions, though he never regained his baseline mental status. We review the literature on interstitial granulomatous dermatitis and encephalitis with immunotherapy.
免疫相关不良反应（irAEs）在接受免疫检查点抑制剂治疗转移性黑色素瘤和其他晚期恶性肿瘤的患者中很常见。皮肤、胃肠道和内分泌（甲状腺）irAEs 最为常见，而神经 irAEs 则很少见。我们报告了一例 73 岁患有痴呆和转移性黑色素瘤的男性患者，他发生了免疫治疗相关性脑炎，随后接受了纳武单抗/伊匹单抗治疗后出现了间质性肉芽肿性皮炎。大剂量皮质类固醇成功治疗了这两种疾病，但他从未恢复到基线精神状态。我们回顾了免疫治疗相关间质性肉芽肿性皮炎和脑炎的文献。
