Weinstock M A, Sober A J
Br J Dermatol. 1987 Mar;116(3):303-10. doi: 10.1111/j.1365-2133.1987.tb05843.x.
An analysis is presented which estimates the risk of progression of lentigo maligna (LM) to lentigo maligna melanoma (LMM) in U.S. whites using three data sources: the Health and Nutrition Examination Survey I for estimation of the age-specific prevalence of LM; the Surveillance, Epidemiology, and End Results Program for estimation of the age-specific incidence of melanoma; and the data from three melanoma registries for estimation of the age-specific case fraction of LMM among all invasive melanomas. The risk varies with age and is likely to be greater than estimated here for patients who present themselves for evaluation of changes in a lesion of LM. Our analysis suggests that the risk of progression from LM to LMM is substantially lower than is commonly believed.
本研究进行了一项分析，利用三个数据源估计美国白人中恶性雀斑（LM）进展为恶性雀斑样痣黑色素瘤（LMM）的风险：一是健康与营养检查调查I，用于估计LM的年龄特异性患病率；二是监测、流行病学和最终结果计划，用于估计黑色素瘤的年龄特异性发病率；三是来自三个黑色素瘤登记处的数据，用于估计所有侵袭性黑色素瘤中LMM的年龄特异性病例比例。风险随年龄而异，对于那些因LM病变变化前来评估的患者，实际风险可能高于此处估计值。我们的分析表明，从LM进展为LMM的风险远低于普遍认知。
