Hepatology at Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, 90.050-170, Brazil.
Obesity Treatment Center of Santa Casa Hospital, Porto Alegre, 90.020-090, Brazil.
Obes Surg. 2022 Aug;32(8):2658-2663. doi: 10.1007/s11695-022-06127-4. Epub 2022 Jun 7.
Non-alcoholic fatty liver disease (NAFLD) has become a challenge in public health, as the prevalence of obesity and overweight has been increasing. It has been observed that serum ferritin (SF) levels are commonly elevated in NAFLD patients.
To assess the relationship between SF levels and NAFLD, exploring the role of SF as a non-invasive marker of NAFLD.
Clinical, anthropometric, laboratory, and histological data of patients with obesity who underwent bariatric surgery in a reference center in Brazil were retrospectively evaluated. Data were collected in the preoperative period up to the first year postoperatively.
A total of 431 patients were analyzed. The prevalence of hyperferritinemia was 18% in the preoperative period and 14% 1 year after the surgery. After multiple regression analysis, elevated SF was not an independent predictor of steatosis, non-alcoholic steatohepatitis (NASH), or liver fibrosis.
Increased SF levels are common in patients with NAFLD; however, SF was not considered an independent predictor of steatosis, NASH, or fibrosis.
随着肥胖和超重的患病率不断增加，非酒精性脂肪性肝病（NAFLD）已成为公共卫生领域的一大挑战。研究发现，NAFLD 患者的血清铁蛋白（SF）水平通常升高。
评估 SF 水平与 NAFLD 之间的关系，探讨 SF 作为 NAFLD 非侵入性标志物的作用。
回顾性分析巴西一家参考中心接受减重手术的肥胖患者的临床、人体测量学、实验室和组织学数据。数据采集时间为术前至术后 1 年。
共分析了 431 名患者。术前高血清铁蛋白血症的患病率为 18%，术后 1 年为 14%。经过多变量回归分析，SF 升高不是脂肪变性、非酒精性脂肪性肝炎（NASH）或肝纤维化的独立预测因子。
NAFLD 患者 SF 水平升高较为常见；然而，SF 不能作为脂肪变性、NASH 或纤维化的独立预测因子。
