West China Hospital, Sichuan University, Department of Endocrinology, Chengdu, Sichuan, China.
West China Hospital, Sichuan University, Department of Outpatient, Chengdu, Sichuan, China.
PeerJ. 2023 Oct 26;11:e16267. doi: 10.7717/peerj.16267. eCollection 2023.
The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Accumulating evidence suggests that serum ferritin and uric acid (UA) are strongly associated with the risk of NAFLD, but no consensus has been reached.
We sought to demonstrate the association between serum ferritin, UA levels, and NAFLD risk in a large cohort study.
We separated 2,049 patients into non-NAFLD and NAFLD groups. The NAFLD group had four subgroups based on serum ferritin and four subgroups based on UA quartile levels. We used binary logistic regression to evaluate the correlation between serum ferritin, UA, and NAFLD. Additionally, an area under the curve (AUC) of receiver operating characteristic analysis (ROC) was used to predict the diagnostic value of combined serum ferritin and UA for NAFLD.
Serum ferritin and UA levels were higher in the NAFLD group compared with the non-NAFLD group. Serum lipid and liver transaminase concentrations were elevated with the increase of serum ferritin and UA. The logistic regression results showed an independent correlation between serum ferritin, UA, and NAFLD. In the NAFLD group, the AUC value of serum ferritin and UA was 0.771.
Increased serum ferritin and UA levels are independent risk factors for NAFLD. Increased serum UA is a stronger risk factor for NAFLD than elevated serum ferritin. Serum ferritin and UA can be important predictors of NAFLD risk.
非酒精性脂肪性肝病（NAFLD）的患病率在全球范围内呈上升趋势。越来越多的证据表明，血清铁蛋白和尿酸（UA）与 NAFLD 的风险密切相关，但尚未达成共识。
我们旨在通过一项大型队列研究证明血清铁蛋白、UA 水平与 NAFLD 风险之间的关联。
我们将 2049 例患者分为非 NAFLD 组和 NAFLD 组。根据血清铁蛋白和 UA 四分位水平，将 NAFLD 组分为四组亚组。我们使用二项逻辑回归评估血清铁蛋白、UA 与 NAFLD 之间的相关性。此外，还使用受试者工作特征曲线（ROC）下面积（AUC）评估联合血清铁蛋白和 UA 对 NAFLD 的诊断价值。
与非 NAFLD 组相比，NAFLD 组的血清铁蛋白和 UA 水平更高。随着血清铁蛋白和 UA 的升高，血清脂质和肝转氨酶浓度也升高。逻辑回归结果表明，血清铁蛋白、UA 与 NAFLD 之间存在独立相关性。在 NAFLD 组中，血清铁蛋白和 UA 的 AUC 值为 0.771。
血清铁蛋白和 UA 水平升高是 NAFLD 的独立危险因素。与血清铁蛋白相比，血清 UA 升高是 NAFLD 的更强危险因素。血清铁蛋白和 UA 可作为 NAFLD 风险的重要预测指标。
