COL1A1 and FGFR2 Single-Nucleotide Polymorphisms Found in Class II and Class III Skeletal Malocclusions in Javanese Population.

OBJECTIVE

The aim of this article is to analyze and compare the presence of single-nucleotide polymorphisms (SNPs) of and in class II and class III Javanese populations.

MATERIALS AND METHODS

Cephalometric radiographs from total 63 patients of class II and III were analyzed. SNP analysis was performed based on both and sequences amplified from total DNA of patients' fresh blood. Principal component analysis was done to calculate the data and find the correlation of the cephalometric indicators influenced by each mutation. -test and Mann-Whitney analysis were performed to check the significance of differences occurred in each studied parameter ( < 0.05).

RESULT

There were three SNPs found in class II and only two in class III, while three SNPs found in both classes. Class II phenotype seemed to be strongly influenced by Y-axis and mandibular plane angle, while class III by lower gonial angle and mandibular plane angle.

CONCLUSION

Based on this study, we suggest that rs2249492 of and rs2981582 of play important roles in class III, while rs2277632 of and rs2981582 of play important role in class II skeletal malocclusion in Javanese population.