Niemiec Paweł, Jarosz Alicja, Nowak Tomasz, Balcerzyk-Matić Anna, Iwanicki Tomasz, Iwanicka Joanna, Gawron Katarzyna, Kalita Marcin, Górczyńska-Kosiorz Sylwia, Kania Wojciech, Szyluk Karol
Department of Biochemistry and Medical Genetics, Faculty of Health Sciences in Katowice, The Medical University of Silesia in Katowice, Medyków 18, 40-752 Katowice, Poland.
Department of Molecular Biology and Genetics, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, Medykow 18, 40-752 Katowice, Poland.
Int J Mol Sci. 2024 Dec 9;25(23):13221. doi: 10.3390/ijms252313221.
The gene encodes the α1 chain of type I collagen, and the data reported so far demonstrate that its polymorphic variants may affect biomechanical properties of bones, muscles, and tendons, and contribute to musculoskeletal disorders. Given, however, limited research on these variants in tendon pathology, we analyzed the impact of polymorphisms on the tendinopathy phenotype and the effectiveness of platelet-rich plasma (PRP) treatment for tennis elbow. Pain perception and therapy outcomes were analyzed from baseline, i.e., before PRP injection to two years post-PRP injection in a cohort of 107 patients. The study focused on seven variants: rs2249492 (C/T), rs2586488 (A/G), rs2075558 (A/C), rs2253369 (C/T), rs35231764 (A/G), rs1800012 (C/A), and rs9898186 (C/T). We demonstrated that carriers of the TT/CT (rs2249492), AA/AC (rs1800012), and TT/CT (rs9898186) genotypes reported pain related to injury more frequently than subjects with other variants, also in the context of performing specific activities and other pain characteristics. These polymorphisms did not significantly influence therapy effectiveness, although rs35231764 showed a moderate effect. In conclusion, the T (rs2249492), A (rs1800012), and T (rs9898186) alleles of gene are risk factors for pain perception in tennis elbow patients, but do not appear to substantially impact PRP treatment outcomes.
该基因编码I型胶原蛋白的α1链，目前报道的数据表明，其多态性变体可能影响骨骼、肌肉和肌腱的生物力学特性，并导致肌肉骨骼疾病。然而，鉴于目前对这些变体在肌腱病理学方面的研究有限，我们分析了多态性对肌腱病表型的影响以及富血小板血浆（PRP）治疗网球肘的有效性。对107例患者从基线（即PRP注射前）到PRP注射后两年的疼痛感知和治疗结果进行了分析。该研究聚焦于7个变体：rs2249492（C/T）、rs2586488（A/G）、rs2075558（A/C）、rs2253369（C/T）、rs35231764（A/G）、rs1800012（C/A）和rs9898186（C/T）。我们发现，TT/CT（rs2249492）、AA/AC（rs1800012）和TT/CT（rs9898186）基因型的携带者比其他变体的受试者更频繁地报告与损伤相关的疼痛，在进行特定活动和其他疼痛特征方面也是如此。这些多态性对治疗效果没有显著影响，尽管rs35231764显示出中等程度的影响。总之，该基因的T（rs2249492）、A（rs1800012）和T（rs9898186）等位基因是网球肘患者疼痛感知的危险因素，但似乎对PRP治疗结果没有实质性影响。
