From the Family Medicine Academy, Qassim Health Cluster, Buraidah, Saudi Arabia (Dr Rabbani); Health Services Academy, Islamabad, Pakistan (Dr Razzaq); Department of Medicine, Aga Khan University, Karachi, Pakistan (Dr Irfan); Institute for Social Marketing and Health, University of Stirling, Scotland, United Kingdom (Dr Semple); Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan (Dr Nafees); National Heart and Lung Institute (NHLI), Imperial College London, United Kingdom (Dr Nafees).
J Occup Environ Med. 2022 Sep 1;64(9):761-765. doi: 10.1097/JOM.0000000000002573. Epub 2022 Jun 11.
We assessed the association of formaldehyde, carbon monoxide (CO), and particulate matter (PM 2.5 ) with respiratory symptoms, asthma, and post-bronchodilator reversibility.
We included 1629 adults in a community-based cross-sectional study in Karachi in 2015. Data were collected using the American Thoracic Society respiratory questionnaire and spirometry (available for 930 participants). YesAir eight-channel monitor was used for measuring concentrations of formaldehyde and CO, whereas PM 2.5 was measured using UCB PATS.
Higher levels of formaldehyde and CO were associated with cough, phlegm, and wheeze, whereas those of PM 2.5 were associated with shortness of breath and presence of any of the respiratory symptoms (combined), as well as a "lower" risk of cough, phlegm, and bronchitis.
Poorer household air quality was associated with poorer respiratory health in this population; however, further studies with a robust exposure assessment are required.
评估甲醛、一氧化碳（CO）和细颗粒物（PM 2.5）与呼吸症状、哮喘和支气管扩张后可恢复性之间的关联。
我们在 2015 年于卡拉奇进行了一项基于社区的横断面研究，共纳入了 1629 名成年人。数据采集采用美国胸科学会呼吸问卷和肺量计（适用于 930 名参与者）。使用 YesAir 八通道监测仪测量甲醛和 CO 的浓度，而使用 UCB PATS 测量 PM 2.5。
较高水平的甲醛和 CO 与咳嗽、咳痰和喘息有关，而 PM 2.5 则与呼吸急促和出现任何呼吸症状（综合）以及咳嗽、咳痰和支气管炎的“较低”风险有关。
在该人群中，较差的室内空气质量与较差的呼吸健康有关；然而，需要进行具有稳健暴露评估的进一步研究。
