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婴儿合并囊性纤维化和进行性家族性肝内胆汁淤积症中早发性脓肿分枝杆菌复合感染:病例报告及文献复习。

Early Disseminated Mycobacterium Abscessus Complex Infection in an Infant with Coexisting Cystic Fibrosis and Progressive Familial Intrahepatic Cholestasis: Case report and literature review.

机构信息

Department of Microbiology, Royal Hospital, Muscat, Oman.

Department of Clinical Microbiology, Oman Medical Specialty Board, Muscat, Oman.

出版信息

Sultan Qaboos Univ Med J. 2022 May;22(2):295-299. doi: 10.18295/squmj.6.2021.089. Epub 2022 May 26.

Abstract

(MABSC) is a rapidly growing and may rarely cause disseminated infections in immunocompromised patients. In patients with cystic fibrosis (CF), it peaks between the ages of 11 and 15 years. We present a five-month-old infant with coexisting CF and progressive familial intrahepatic cholestasis (PFIC) who had pulmonary and cutaneous dissemination of MABSC infection. The management of this disseminated infection in an infant with two coexisting chronic diseases was challenging and resulted in the rapid deterioration of lung function and progression of PFIC to liver cirrhosis with a fatal outcome.

摘要

(MABSC)是一种快速增长的病原体,在免疫功能低下的患者中可能很少引起播散性感染。在囊性纤维化(CF)患者中,其发病高峰在 11 至 15 岁之间。我们报告了一例五个月大的婴儿,同时患有 CF 和进行性家族性肝内胆汁淤积症(PFIC),患有 MABSC 感染的肺部和皮肤播散。在一个同时患有两种慢性疾病的婴儿中,这种播散性感染的治疗极具挑战性,导致肺功能迅速恶化,PFIC 进展为肝硬化,最终导致死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3436/9155037/5298e50add45/squmj2205-295-299f1.jpg

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