[乙醇和过氧化氢酶抑制剂氨基三唑对大鼠心肌脂质过氧化的影响]
[Effect of ethanol and the catalase inhibitor aminotriazole on lipid peroxidation in the rat myocardium].
作者信息
Panchenko L F, Pirozhkov S V, Popova S V, Antonenkov V D
出版信息
Biull Eksp Biol Med. 1987 Apr;103(4):407-10.
The influence of chronic alcohol consumption and catalase inhibitor aminotriazole administration on the level of nonenzymatic lipid peroxidation has been studied in the rat myocardium. It was demonstrated that combined as well as separate treatment with ethanol or aminotriazole elevated the levels of chemiluminescence and enhanced the rate of accumulation of thiobarbituric acid-reactive products in the nuclei-free and total particulate fraction of the rat heart homogenate. The most pronounced effect was noted during combined application of ethanol and aminotriazole. The induction of chemiluminescence by ethanol was prevented by addition of natural (vitamin E, reduced glutathione) or artificial (dibunol) antioxidants into the incubation media. A putative role of the myocardial catalase-containing micro-peroxisomes in stimulation of the intracellular lipid peroxidation is discussed.
研究了长期饮酒和给予过氧化氢酶抑制剂氨基三唑对大鼠心肌非酶促脂质过氧化水平的影响。结果表明，乙醇或氨基三唑联合及单独处理均可提高大鼠心脏匀浆无核部分和总颗粒部分的化学发光水平，并增强硫代巴比妥酸反应产物的积累速率。乙醇和氨基三唑联合应用时效果最为显著。在孵育介质中添加天然抗氧化剂（维生素E、还原型谷胱甘肽）或人工抗氧化剂（二丁酚）可阻止乙醇诱导的化学发光。文中讨论了心肌含过氧化氢酶的微过氧化物酶体在刺激细胞内脂质过氧化中的假定作用。
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