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[自发性高血压大鼠与正常血压大鼠F2代杂种中钠、钾协同转运率、红细胞钙水平及血压遗传的遗传分析]

[Genetic analysis of inheritance of Na+, K+-cotransport rate, calcium level in erythrocytes and blood pressure in F2 hybrids of spontaneously hypertensive and normotensive rats].

作者信息

Kotelevtsev Iu V, Orlov S N, Pokudin N I, Agnaev V M, Postnov Iu V

出版信息

Biull Eksp Biol Med. 1987 Apr;103(4):456-8.

PMID:3567342
Abstract

Positive correlation between Na+, K+-cotransport speed values in platelets and arterial pressure (AP) medium values was disclosed in F2 murine hybrids with spontaneous hypertension (SHT) and in WKY controls as was the correlation between Ca erythrocytic levels and the value of delta AP-AP1-AP2, with AP1--systolic AP measured in alert animals, AP2--medium AP measured directly in anesthetized rats. The data obtained during the aforementioned experimental series together with those obtained in the premorbid stage provided for a conclusion that all the signs considered were inherited in chain with a positive deposit in AP and played an important role in the pathogenesis of primary arterial hypertension.

摘要

在患有自发性高血压(SHT)的F2代小鼠杂种以及WKY对照中,发现血小板中Na +,K + - 协同转运速度值与动脉压(AP)平均值之间存在正相关,红细胞中Ca水平与ΔAP - AP1 - AP2值之间也存在正相关,其中AP1是在清醒动物中测量的收缩压AP,AP2是直接在麻醉大鼠中测量的平均动脉压。在上述实验系列中获得的数据以及在疾病前期获得的数据表明,所有考虑的体征都以AP的正性沉积连锁遗传,并在原发性动脉高血压的发病机制中起重要作用。

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