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近年来对 HES6 在癌症中的作用的认识进展。

Recent advances in understanding the role of HES6 in cancers.

机构信息

Université Côte d'Azur, France.

Inserm, Biology and Pathologies of melanocytes, team1, Equipe labellisée Ligue 2020 and Equipe labellisée ARC 2019, Centre Méditerranéen de Médecine Moléculaire, Nice, France.

出版信息

Theranostics. 2022 May 20;12(9):4374-4385. doi: 10.7150/thno.72966. eCollection 2022.

DOI:10.7150/thno.72966
PMID:35673577
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9169368/
Abstract

The NOTCH signaling system regulates a variety of cellular processes during embryonic development and homeostasis maintenance in different tissues and contexts. Hence, dysregulation of NOTCH signaling is associated with a plethora of human cancers, and there have been multiple efforts to target key components of this pathway. In this review, we briefly highlight the latest research advances in understanding HES6, a poorly studied component of the NOTCH pathway. We summarize the role of HES6 in cancers with a focus on uveal melanoma. Finally, we discuss the ongoing efforts to target the NOTCH-HES6 axis in cancers.

摘要

NOTCH 信号系统在胚胎发育和不同组织及环境中的内稳态维持过程中调节多种细胞过程。因此，NOTCH 信号的失调与多种人类癌症相关联，并且已经有多种针对该途径的关键成分的靶向治疗方法。在这篇综述中，我们简要地强调了理解 NOTCH 途径中研究较少的一个成分 HES6 的最新研究进展。我们总结了 HES6 在癌症中的作用，重点是葡萄膜黑色素瘤。最后，我们讨论了在癌症中靶向 NOTCH-HES6 轴的正在进行的努力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e567/9169368/d1e3a2c8d0b5/thnov12p4374g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e567/9169368/3df1218e7160/thnov12p4374g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e567/9169368/98ef82627be7/thnov12p4374g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e567/9169368/ee702fa4f68a/thnov12p4374g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e567/9169368/aa5ba8973ed5/thnov12p4374g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e567/9169368/d1e3a2c8d0b5/thnov12p4374g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e567/9169368/3df1218e7160/thnov12p4374g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e567/9169368/98ef82627be7/thnov12p4374g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e567/9169368/ee702fa4f68a/thnov12p4374g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e567/9169368/aa5ba8973ed5/thnov12p4374g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e567/9169368/d1e3a2c8d0b5/thnov12p4374g005.jpg

相似文献

[1]
Recent advances in understanding the role of HES6 in cancers.

Theranostics. 2022

[2]
Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease.

Cell Death Differ. 2021-6

[3]
HES6 promotes prostate cancer aggressiveness independently of Notch signalling.

J Cell Mol Med. 2015-7

[4]
A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis.

Dev Biol. 2005-5-15

[5]
[Transcription factor HES6, a key player in uveal melanoma].

Med Sci (Paris). 2022

[6]
HES6-1 and HES6-2 function through different mechanisms during neuronal differentiation.

PLoS One. 2010-12-2

[7]
Overexpression of HES6 has prognostic value and promotes metastasis via the Wnt/β-catenin signaling pathway in colorectal cancer.

Oncol Rep. 2018-7-2

[8]
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Invest Ophthalmol Vis Sci. 2013-1-9

[9]
Basic helix-loop-helix gene Hes6 delineates the sensory hair cell lineage in the inner ear.

Dev Dyn. 2006-6

[10]
Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer.

Int J Oncol. 2007-8

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[3]
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Genes (Basel). 2024-9-20

[4]
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Haematologica. 2024-11-1

[5]
Significance of Aneuploidy in Predicting Prognosis and Treatment Response of Uveal Melanoma.

Curr Med Chem. 2025

[6]
Alveolar type I cells can give rise to KRAS-induced lung adenocarcinoma.

Cell Rep. 2023-12-26

[7]
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Cancers (Basel). 2023-4-19

[8]
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[9]
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本文引用的文献

[1]
Overall Survival Benefit with Tebentafusp in Metastatic Uveal Melanoma.

N Engl J Med. 2021-9-23

[2]
Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression.

Nat Commun. 2021-9-13

[3]
Immune marker signature helps to predict survival in uveal melanoma.

Math Biosci Eng. 2021-5-10

[4]
Translation of single-cell transcriptomic analysis of uveal melanomas to clinical oncology.

Prog Retin Eye Res. 2021-11

[5]
CCMAlnc Promotes the Malignance of Colorectal Cancer by Modulating the Interaction Between miR-5001-5p and Its Target mRNA.

Front Cell Dev Biol. 2020-12-16

[6]
Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease.

Cell Death Differ. 2021-6

[7]
Gamma Secretase Inhibitors in Cancer: A Current Perspective on Clinical Performance.

Oncologist. 2021-4

[8]
The complex relationship between MITF and the immune system: a Melanoma ImmunoTherapy (response) Factor?

Mol Cancer. 2020-12-5

[9]
Notch in Head and Neck Cancer.

Adv Exp Med Biol. 2021

[10]
Endoplasmic reticulum stress mediates resistance to BCL-2 inhibitor in uveal melanoma cells.

Cell Death Discov. 2020-4-17

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