Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, 68169 Mannheim, Germany.
Int J Mol Sci. 2023 Jan 15;24(2):1725. doi: 10.3390/ijms24021725.
The erythroferrone gene (), also termed , belongs to the C1q tumor necrosis factor-related protein (CTRP) family. Despite multiple reports about the involvement of CTRPs in cancer, the role of ERFE in cancer progression is largely unknown. We previously found that was upregulated in erythroid progenitors in myelodysplastic syndromes and strongly predicted overall survival. To understand the potential molecular interactions and identify cues for further functional investigation and the prognostic impact of ERFE in other malignancies, we performed a pan-cancer in silico analysis utilizing the Cancer Genome Atlas datasets. Our analysis shows that the mRNA is significantly overexpressed in 22 tumors and affects the prognosis in 11 cancer types. In certain tumors such as breast cancer and adrenocortical carcinoma, overexpression has been associated with the presence of oncogenic mutations and a higher tumor mutational burden. The expression of is co-regulated with the factors and pathways involved in cancer progression and metastasis, including activated pathways of the cell cycle, extracellular matrix/tumor microenvironment, G protein-coupled receptor, NOTCH, WNT, and PI3 kinase-AKT. Moreover, expression influences intratumoral immune cell infiltration. Conclusively, is aberrantly expressed in pan-cancer and can potentially function as a prognostic biomarker based on its putative functions during tumorigenesis and tumor development.
红细胞生成素基因（），也称为，属于 C1q 肿瘤坏死因子相关蛋白（CTRP）家族。尽管有多项关于 CTRP 参与癌症的报道，但 ERFE 在癌症进展中的作用在很大程度上尚不清楚。我们之前发现，在骨髓增生异常综合征的红细胞祖细胞中上调，并强烈预测总生存期。为了了解潜在的分子相互作用，并确定进一步功能研究和 ERFE 在其他恶性肿瘤中的预后影响的线索，我们利用癌症基因组图谱数据集进行了泛癌症的计算机分析。我们的分析表明，在 22 种肿瘤中，mRNA 显著过表达，并影响 11 种癌症类型的预后。在某些肿瘤中，如乳腺癌和肾上腺皮质癌，过表达与致癌突变的存在和更高的肿瘤突变负担有关。的表达与癌症进展和转移涉及的因子和途径（包括细胞周期、细胞外基质/肿瘤微环境、G 蛋白偶联受体、NOTCH、WNT 和 PI3 激酶-AKT 的激活途径）共同调节。此外，表达影响肿瘤内免疫细胞浸润。总之，在泛癌中异常表达，并且可以根据其在肿瘤发生和肿瘤发展过程中的潜在功能作为预后生物标志物。
