微量白蛋白尿合并估算肾小球滤过率降低：冠状动脉介入治疗后对比剂诱导急性肾损伤的早期危险因素。

Microalbuminuria Complicated with Low Estimated Glomerular Filtration Rate: Early Risk Factors for Contrast-Induced Acute Kidney Injury After Coronary Intervention.

机构信息

Department of Cardiology, Jinling Hospital, Nanjing University, School of Medicine, Nanjing, Jiangsu, China (mainland).

School of Medicine, Southeast University, Nanjing, Jiangsu, China (mainland).

出版信息

Med Sci Monit. 2022 May 23;28:e935455. doi: 10.12659/MSM.935455.

BACKGROUND We aimed to investigate the impact of microalbuminuria complicated with low estimate glomerular filtration rate (eGFR) on the incidence and prognosis of contrast-induced acute kidney injury (CI-AKI) in patients with coronary artery disease after coronary intervention. MATERIAL AND METHODS A total of 943 patients were enrolled in the study. Based on microalbumin/creatinine (ACR) measurements, the patients were divided into a microalbuminuria cohort (MA; 222 patients) and a normal albuminuria cohort (NA; 721 patients). According to eGFR levels, the cohorts were further subdivided into normal, mild, moderate, and severe renal dysfunction groups. The basic data and indicators of all enrolled patients were collected. The patients were followed up at 30 days, 6 months, 1 year, and 3 years after surgery. RESULTS The overall incidence of CI-AKI in the MA cohort was higher than that in the NA cohort (17.6% vs 8.2%, P.

背景

本研究旨在探讨合并估算肾小球滤过率（eGFR）降低的微量白蛋白尿对经皮冠状动脉介入治疗（PCI）后合并冠状动脉疾病患者对比剂诱导急性肾损伤（CI-AKI）的发生和预后的影响。

材料和方法

共纳入 943 例患者。根据微量白蛋白/肌酐（ACR）的测量值，将患者分为微量白蛋白尿组（MA 组，222 例）和正常白蛋白尿组（NA 组，721 例）。根据 eGFR 水平，将两组进一步细分为正常、轻度、中度和重度肾功能障碍组。收集所有纳入患者的基本数据和指标。术后 30 天、6 个月、1 年和 3 年对患者进行随访。