de Maublanc M A, Denys I, Vilcoq J R, Veith F, Asselain B, Calle R
Bull Cancer. 1987;74(1):23-30.
This study reports the results of 649 drill biopsies performed on breast tumors before any treatment. Diagnostic of malignancy was achieved with a drill biopsy in 89% cases (579/649 procedures). Pathological subtypes, i.e. common infiltrating types, special pathological types, were determined in 98% cases (566/579), while histo-prognostic grading, according to Scarff, Bloom and Richardson, was performed in 98% of the common infiltrating type carcinomas (498/507). Reliability of the technique was related to the tumor size 57%, 87.5%, 93.5% and 98.5% in T1, T2, T3 and T4 tumors (TNM classification), respectively. Comparative reliability of the three different operators was 86.5%, 88.5% and 92%, and was related to their technical experience. This study has demonstrated the diagnostic value of a "malignant" drill biopsy, which is independent of the results of the initial radiological and clinical work-up: suspicious or malignant (group A: 635 cases, or non-suspicious group B: 14 cases). However, "non malignant" drill biopsy has no value and should not be conclusive.
本研究报告了对649例乳腺肿瘤在进行任何治疗前进行钻孔活检的结果。钻孔活检在89%的病例（579/649例操作）中确诊为恶性。98%的病例（566/579）确定了病理亚型，即常见浸润型、特殊病理类型，而在98%的常见浸润型癌（498/507）中根据斯卡夫、布鲁姆和理查森标准进行了组织预后分级。该技术的可靠性与肿瘤大小相关，在T1、T2、T3和T4肿瘤（TNM分类）中分别为57%、87.5%、93.5%和98.5%。三位不同操作者的比较可靠性分别为86.5%、88.5%和92%，且与他们的技术经验有关。本研究证明了“恶性”钻孔活检的诊断价值，其独立于初始影像学和临床检查结果：可疑或恶性（A组：635例）或非可疑（B组：14例）。然而，“非恶性”钻孔活检没有价值，不应作为定论。
