Veith F, Picco C
Bull Cancer. 1977;64(4):537-55.
Two histological factors to be taken into consideration for prognosis in pretreatment schedules of breast cancer have been studied on a group of 352 cases treated by non-mutilating therapeutics at the Fondation Curie between 1960 and 1970. The tumour material the slides of which we have reexamined "blindly", i.e. ignoring the evolution of the case had been obtained mostly by drill-biopsy. Histological groups and types have been determined following an analytical classification for computer purpose. The degree of malignancy was calculated with the method of Scarff-Bloom-Richardson. The analyzed data have been memorized on computer and then confronted with the elements of the T.N.M. classification and the survival of the patients involved. It appeared that if drill-biopsie have been performed correctly the histological type may be defined in eighty percent of cases. And it is likewise possible to calculate the histological grade of malignancy for each mammary cancer. With such a material the value for prognosis by means of the Scarff-Bloom-Richardson method still remains if applied only to adenocarcinoma of the "common infiltrating type".
1960年至1970年间，在居里基金会，对一组352例采用非致残性疗法治疗的乳腺癌患者，研究了在预处理方案中影响预后的两个组织学因素。我们“盲目地”重新检查了切片的肿瘤材料，即忽略病例的进展情况，这些材料大多通过钻取活检获得。按照计算机分析分类确定了组织学组和类型。采用斯卡夫-布鲁姆-理查森方法计算恶性程度。分析的数据已存储在计算机中，然后与TNM分类要素及相关患者的生存率进行对比。结果显示，如果钻取活检操作正确，80%的病例可以确定组织学类型。同样，对于每一例乳腺癌也能够计算出组织学恶性分级。利用这样的材料，通过斯卡夫-布鲁姆-理查森方法进行预后评估，若仅应用于“常见浸润型”腺癌，其价值依然存在。
