Department of Morphofunctional Sciences I - Histology, Grigore T. Popa University of Medicine and Pharmacy, Iaşi, Romania;
Rom J Morphol Embryol. 2021 Oct-Dec;62(4):1029-1034. doi: 10.47162/RJME.62.4.15.
Screening programs using Papanicolaou smear along with human papillomavirus (HPV) testing led to a significantly decrease of cervical cancer rates. Nevertheless, both assessments have limited specificity for revealing cervical high-grade lesions. The main problem is how to identify the real precursor of cervical squamous cell carcinomas (SCC), namely high-grade squamous intraepithelial lesions (HSIL).
The aim of our study was to conclude if ProEx C might be used as a marker for high-grade cervical intraepithelial neoplasia (CIN).
In this study, we detected the immunochemical expression of anti-ProEx C antibody in liquid-based cytology (LBC) samples. We analyzed a total number of 125 cervical cytology specimens.
In 48% of all cases, ProEx C was found to be positive. The percentage increased from 0% in negative for intraepithelial lesion or malignancy (NILM) cases to 100% in SCC cases.
ProEx C may be utilized to improve the accuracy of cytological diagnosis on cervical smears, according to the findings of this study. This marker is also useful in detecting unrevealed high-grade lesions on atypical squamous cells of undetermined significance (ASC-US), low-grade squamous intraepithelial lesions (LSIL) smears, being very useful in establishing the conduct of these cases.
巴氏涂片联合人乳头瘤病毒（HPV）检测的筛查方案显著降低了宫颈癌的发病率。然而，这两种评估方法对揭示宫颈高级别病变的特异性均有限。主要问题是如何确定宫颈癌鳞状细胞癌（SCC）的真正前体，即高级别鳞状上皮内病变（HSIL）。
我们的研究目的是确定 ProEx C 是否可作为高级别宫颈上皮内瘤变（CIN）的标志物。
在这项研究中，我们检测了液基细胞学（LBC）样本中抗 ProEx C 抗体的免疫化学表达。我们分析了总共 125 例宫颈细胞学标本。
在所有病例中，有 48%发现 ProEx C 呈阳性。这一比例从阴性上皮内病变或恶性肿瘤（NILM）病例的 0%增加到 SCC 病例的 100%。
根据这项研究的结果，ProEx C 可用于提高宫颈涂片细胞学诊断的准确性。该标志物在检测不明显的高级别病变方面也很有用，包括非典型鳞状细胞不能明确意义（ASC-US）、低级别鳞状上皮内病变（LSIL）涂片，对于这些病例的处理非常有用。
