肺纤维化和肺癌中的 DNA 甲基化。
DNA methylation in pulmonary fibrosis and lung cancer.
机构信息
Department of Geriatrics, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Clinical Laboratory, Xiangya Hospital of Central South University, Changsha, Hunan, China.
出版信息
Expert Rev Respir Med. 2022 May;16(5):519-528. doi: 10.1080/17476348.2022.2085091. Epub 2022 Jun 8.
INTRODUCTION
Pulmonary fibrosis is an age-related, progressive, and fatal disease with a median survival of 3-5 years after diagnosis; idiopathic pulmonary fibrosis (IPF) is the most common type. It is characterized by fibroblast proliferation and accumulation of excessive extracellular matrix. Patients with IPF are at increased risk for lung cancer. Epigenetic mechanisms are involved in lung fibrosis and cancer, and DNA methylation is critical in disease pathogenesis and progression. Therefore, studies of DNA methylation contribute to better understanding of the underlying mechanisms of these two respiratory diseases, and can offer novel diagnostic and treatment options.
AREAS COVERED
This review discusses the latest advances in our understanding of epigenetic factors related to DNA methylation that impact development of lung cancer and pulmonary fibrosis, discusses the role of DNA methylation in promoting or inhibiting these diseases, and proposes its potential clinical significance in disease diagnosis and treatment.
EXPERT OPINION
DNA methylation plays a critical role in lung cancer and fibrosis pathogenesis. DNA methylation offers a new biomarker for disease diagnosis or monitoring, and provides a new therapeutic target for treatment.
简介
肺纤维化是一种与年龄相关的进行性致死性疾病，诊断后中位生存期为 3-5 年；特发性肺纤维化（IPF）是最常见的类型。其特征为成纤维细胞增殖和细胞外基质过度积累。IPF 患者发生肺癌的风险增加。表观遗传机制参与肺纤维化和癌症，而 DNA 甲基化在疾病发病机制和进展中起关键作用。因此，对 DNA 甲基化的研究有助于更好地理解这两种呼吸系统疾病的潜在机制，并能提供新的诊断和治疗选择。
涵盖领域
本文综述了我们对与 DNA 甲基化相关的表观遗传因素的最新认识，这些因素影响肺癌和肺纤维化的发生，并讨论了 DNA 甲基化在促进或抑制这些疾病中的作用，以及其在疾病诊断和治疗中的潜在临床意义。
专家意见
DNA 甲基化在肺癌和纤维化发病机制中起关键作用。DNA 甲基化可作为疾病诊断或监测的新型生物标志物，并为治疗提供新的治疗靶点。
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