Department of Pediatric Pulmonology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
J Asthma. 2023 Apr;60(4):682-690. doi: 10.1080/02770903.2022.2087670. Epub 2022 Jun 17.
This study aimed to analyze the risk factors affecting lung function in children with asthma based on clinical data to advice on clinical treatment and prognosis.
This study included newly diagnosed patients with asthma admitted to the Respiratory Department of Chengdu Women's and Children's Central Hospital in Sichuan from July 2020 to June 2021. The factors associated with lung function were analyzed using univariate and multivariate linear regression with the forward method, while factors affecting lung ventilation function were analyzed using multivariate logistic regression.
Sixty percent of the patients had normal lung function. Age was significantly negatively correlated with forced vital capacity (FVC)/FVC ( = -1.385, = 0.001), FEV/FEV ( = -2.092, < 0.001), and FEV%/FEV% ( = -0.834, = 0.001). Body mass index (BMI) for age score ( = 1.661, = 0.045) and cesarean delivery ( = 4.471, = 0.013) were significantly positively correlated with FVC/FVC. Birth weight was significantly positively correlated with FEV/FEV ( = 4.593, = 0.027). Multivariate logistic regression analysis revealed that age ≥6 years and cough variant asthma (CVA) were risk factors for abnormal lung function.
Age, BMI for age score, mode of delivery, and birth weight were significantly correlated with lung function in children with asthma. Furthermore, children with asthma and normal lung function were more likely to be overlooked. More attention should be given to children with asthma and normal lung function, and CVA.
本研究旨在分析基于临床数据的哮喘患儿肺功能的影响因素，为临床治疗和预后提供建议。
本研究纳入了 2020 年 7 月至 2021 年 6 月在四川成都妇女儿童中心医院呼吸科新诊断为哮喘的患者。采用向前法进行单因素和多因素线性回归分析，探讨与肺功能相关的因素，采用多因素 logistic 回归分析影响肺通气功能的因素。
60%的患者肺功能正常。年龄与用力肺活量(FVC)/FVC( = -1.385, = 0.001)、FEV/FEV( = -2.092, < 0.001)和 FEV%/FEV%( = -0.834, = 0.001)呈显著负相关。年龄别体重指数(BMI)得分( = 1.661, = 0.045)和剖宫产( = 4.471, = 0.013)与 FVC/FVC 呈显著正相关。出生体重与 FEV/FEV( = 4.593, = 0.027)呈显著正相关。多因素 logistic 回归分析显示，年龄≥6 岁和咳嗽变异性哮喘(CVA)是肺功能异常的危险因素。
年龄、BMI 得分、分娩方式和出生体重与哮喘患儿肺功能显著相关。此外，哮喘患儿肺功能正常更易被忽视。应更加关注哮喘患儿和正常肺功能以及 CVA。
