血清维生素A和25-羟基维生素D3（25OHD3）水平作为稳定期哮喘儿童肺功能和生活质量（QOL）的反映指标：一项病例对照研究。
Serum levels of vitamin A and 25-hydroxyvitamin D3 (25OHD3) as reflectors of pulmonary function and quality of life (QOL) in children with stable asthma: A case-control study.
作者信息
Bai Ya-Jie, Dai Ru-Jun
机构信息
5th Department of Pediatric 2nd Department of Pediatric, Cangzhou Central Hospital, Cangzhou, P.R. China.
出版信息
Medicine (Baltimore). 2018 Feb;97(7):e9830. doi: 10.1097/MD.0000000000009830.
BACKGROUND
This study aims to explore the relationship between serum vitamin A and 25-hydroxyvitamin D3 (25OHD3) levels with pulmonary function and quality of life (QOL) in children with stable asthma.
METHODS
A total of 117 cases of children with stable asthma were assigned into the case group and 129 healthy children underwent physical examination during the same period into the control group. Electrochemiluminescence was employed to determine serum vitamin A and 25OHD3 levels. The children with stable asthma were further divided into the mild, moderate, and severe groups according to their degree of asthma. A pulmonary function meter was used to assess the pulmonary function indexes: percentage of forced expiratory volume in 1 sec/predictive value (FEV1%pred), forced vital capacity (FVC), forced expiratory volume in 1 sec/forced vital capacity (FEV1/FVC), peak expiratory flow (PEF), and maximal voluntary ventilation (MVV). The children's quality (QOL) of life with asthma was evaluated by their activities of daily living (ADLs) and Medical Research Council (MRC) scores. Pearson correlation analysis was applied to analyze the correlations of serum vitamin A and 25OHD3 levels with FEV1%pred, FVC, FEV1/FVC, PEF, MVV, ADL, and MRC.
RESULTS
Serum vitamin A and 25OHD3 levels were lower in children with stable asthma than those who were in the control group (P < .05). The severe group showed the lowest FEV1%pred, FVC, FEV1/FVC, PEF, MVV, and ADL scores, and the highest MRC score compared to the mild and moderate groups (all P < .05). Serum vitamin A and 25OHD3 levels were positively correlated with pulmonary function and ADL score in children with stable asthma, while serum vitamin A and 25OHD3 levels were negatively correlated with MRC score (all P < .05). In the case group, serum vitamin A and 25OHD3 levels were positively correlated with serum calcium and phosphorus levels (all P < .05).
CONCLUSION
These findings indicate that increased serum vitamin A and 25OHD3 levels reflect good pulmonary function and good QOL in children with stable asthma.
背景
本研究旨在探讨血清维生素A和25-羟基维生素D3（25OHD3）水平与稳定期哮喘患儿肺功能及生活质量（QOL）之间的关系。
方法
将117例稳定期哮喘患儿纳入病例组，同期129例健康体检儿童纳入对照组。采用电化学发光法测定血清维生素A和25OHD3水平。将稳定期哮喘患儿根据哮喘程度进一步分为轻度、中度和重度组。使用肺功能仪评估肺功能指标：第1秒用力呼气容积/预测值百分比（FEV1%pred）、用力肺活量（FVC）、第1秒用力呼气容积/用力肺活量（FEV1/FVC）、呼气峰值流速（PEF）和最大自主通气量（MVV）。通过日常生活活动（ADL）和医学研究委员会（MRC）评分评估哮喘患儿的生活质量（QOL）。采用Pearson相关分析血清维生素A和25OHD3水平与FEV1%pred、FVC、FEV1/FVC、PEF、MVV、ADL及MRC的相关性。
结果
稳定期哮喘患儿血清维生素A和25OHD3水平低于对照组（P<0.05）。与轻度和中度组相比，重度组的FEV1%pred、FVC、FEV1/FVC、PEF、MVV和ADL评分最低，MRC评分最高（均P<0.05）。稳定期哮喘患儿血清维生素A和25OHD3水平与肺功能及ADL评分呈正相关，而血清维生素A和25OHD3水平与MRC评分呈负相关（均P<0.05）。病例组中，血清维生素A和25OHD3水平与血清钙和磷水平呈正相关（均P<0.05）。
结论
这些发现表明，血清维生素A和25OHD3水平升高反映了稳定期哮喘患儿良好的肺功能和生活质量。
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