儿童时期体重相关人体测量学与儿童晚期肺功能的关联：一项回顾性队列研究。
The associations between weight-related anthropometrics during childhood and lung function in late childhood: a retrospective cohort study.
机构信息
Department of Paediatrics, Stavanger University Hospital, POB 8100, N-4068, Stavanger, Norway.
Department of Clinical Science, University of Bergen, Bergen, Norway.
出版信息
BMC Pulm Med. 2018 Jan 19;18(1):10. doi: 10.1186/s12890-017-0567-3.
BACKGROUND
An association between body weight in childhood and subsequent lung function and asthma has been suggested, but few longitudinal studies exist. Our aim was to explore whether weight-related anthropometric measurements through childhood were associated with lung function in late childhood.
METHODS
From an original nested case-control study, a cohort study was conducted, where lung function was measured in 463 children aged 12.8 years, and anthropometry was measured at several ages from birth through 12.8 years of age. Associations between anthropometrics and lung function were analysed using multiple linear and fractional polynomial regression analysis.
RESULTS
Birthweight and body mass index (BMI; kg/m) at different ages through childhood were positively associated with forced vital capacity in percent of predicted (FVC %) and forced expiratory volume in the first second in percent of predicted (FEV%) at 12.8 years of age. BMI, waist circumference, waist-to-height ratio and skinfolds at 12.8 years of age and the change in BMI from early to late childhood were positively associated with FVC % and FEV% and negatively associated with FEV/FVC and forced expiratory flow at 25-75% of FVC/FVC. Interaction analyses showed that positive associations between anthropometrics other than BMI and lung function were mainly found in girls. Inverse U-shaped associations were found between BMI at the ages of 10.8/11.8 (girls/boys) and 12.8 years (both genders) and FVC % and FEV% at 12.8 years of age.
CONCLUSIONS
Weight-related anthropometrics through childhood may influence lung function in late childhood. These findings may be physiological or associated with air flow limitation. Inverse U-shaped associations suggest a differential impact on lung function in normal-weight and overweight children.
TRIAL REGISTRATION
This study was observational without any health care intervention for the participants. Therefore, no trial registration number is available.
背景
儿童期体重与随后的肺功能和哮喘之间存在关联，但纵向研究较少。我们的目的是探讨儿童期体重相关的人体测量指标是否与儿童晚期的肺功能有关。
方法
从一项原始的嵌套病例对照研究中，开展了一项队列研究，对 463 名 12.8 岁儿童进行了肺功能测量，并在出生到 12.8 岁的几个年龄点测量了人体测量学。使用多元线性和分数多项式回归分析来分析人体测量学与肺功能之间的关系。
结果
出生体重和不同年龄的体重指数（BMI；kg/m）与 12.8 岁时的用力肺活量占预计值百分比（FVC%）和第一秒用力呼气量占预计值百分比（FEV%）呈正相关。12.8 岁时的 BMI、腰围、腰高比和皮褶厚度以及从早期到晚期儿童期 BMI 的变化与 FVC%和 FEV%呈正相关，与 FEV/FVC 和用力呼气流量 25-75%占 FVC/FVC 的比值呈负相关。交互分析表明，BMI 以外的人体测量学与肺功能之间的正相关主要见于女孩。BMI 在 10.8/11.8 岁（女孩/男孩）和 12.8 岁（两性）的年龄以及 FVC%和 FEV%在 12.8 岁时呈反 U 形关系。
结论
儿童期体重相关的人体测量学可能会影响儿童晚期的肺功能。这些发现可能是生理性的，也可能与气流受限有关。反 U 形关联表明，对正常体重和超重儿童的肺功能有不同的影响。
试验注册
本研究为观察性研究，对参与者没有任何医疗干预。因此，没有可用的试验登记号。
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