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比较 CHAOS(慢性腹主动脉闭塞,亚洲多中心)注册研究中腹主动脉下段慢性闭塞的主动脉-股动脉旁路移植术和血管内治疗。

Comparison of Aortobifemoral Bypass and Endovascular Treatment for Chronic Infrarenal Abdominal Aortic Occlusion From the CHAOS (ronic bdominal Aortic cclusion, Aian Multicenter) Registry.

机构信息

Department of Vascular Surgery, Saiseikai Central Hospital, Tokyo, Japan.

Department of Metabolic Medicine, Osaka University, Suita, Japan.

出版信息

J Endovasc Ther. 2023 Dec;30(6):828-837. doi: 10.1177/15266028221098710. Epub 2022 Jun 8.

Abstract

PURPOSE

To directly compare the clinical outcomes of aortobifemoral bypass surgery (ABF) and endovascular treatment (EVT) for chronic total occlusion (CTO) of the infrarenal abdominal aorta (IAA).

MATERIALS AND METHODS

In this retrospective, multicenter study, we used an international database of 436 patients who underwent revascularization for CTO of the IAA between 2007 and 2017 at 30 Asian cardiovascular centers. After excluding 52 patients who underwent axillobifemoral bypass surgery, 384 patients (139 ABFs and 245 EVTs) were included in the analysis. Propensity score-matched analysis was performed to compare clinical results in the periprocedural period and the long-term.

RESULTS

Propensity score matching extracted 88 pairs. Procedure time (ABF; 288 [240-345] minutes vs EVT; 159 [100-205] minutes, p<0.001) and length of hospital stay (17 [12-23] days vs 5 [4-13] days, p<0.001) were significantly shorter in the EVT group than in the ABF group, while the proportions of procedural success (98.9% versus 96.6%, p=0.620), complications (9.1% versus 12.3%, p=0.550), and mortality (2.3% versus 3.8%, p=1.000) were not different between the groups. At 1 months, ABI significantly increased more in the ABF group for both in a limb with the lower (0.56 versus 0.50, p=0.018) and the higher (0.49 versus 0.34, p=0.001) baseline ABI, while the change of the Rutherford category was not significantly different between the groups (p=0.590). At 5 years, compared with the EVT group, the ABF group had significantly better primary patency (89.4±4.3% versus 74.8±4.3%, p=0.035) and survival rates (86.9±4.5% versus 66.2±7.5%, p=0.007). However, there was no significant difference between the groups for secondary patency (100.0%±0.0% versus 93.5%±3.9%, p=0.160) and freedom from target lesion revascularization (TLR) (89.3±4.3% vs 77.3±7.3%, p=0.096).

CONCLUSION

Even with recent advancements in EVT, primary patency was still significantly better for ABF in CTO of the IAA. However, there was no difference between the groups in terms of secondary patency and freedom from TLR at 5 years. Furthermore, there was no difference in procedural success, complications, mortality, and improvement in the Rutherford classification during the periprocedural period, with significantly shorter procedure time and hospital stay in the EVT group.

摘要

目的

直接比较腹主动脉下段慢性全闭塞(CTO)患者行主动脉-股动脉旁路移植术(ABF)和血管内治疗(EVT)的临床结局。

材料与方法

本回顾性、多中心研究使用了亚洲 30 家心血管中心 2007 年至 2017 年间行 IAA 下段 CTO 血运重建的 436 例患者的国际数据库。排除 52 例行腋股旁路移植术的患者后,共有 384 例患者(139 例行 ABF 和 245 例行 EVT)纳入分析。采用倾向评分匹配分析比较围手术期和长期的临床结果。

结果

倾向评分匹配提取了 88 对。EVT 组的手术时间(ABF:288[240-345]min 比 EVT:159[100-205]min,p<0.001)和住院时间(ABF:17[12-23]d 比 EVT:5[4-13]d,p<0.001)明显短于 ABF 组,而手术成功率(98.9%比 96.6%,p=0.620)、并发症(9.1%比 12.3%,p=0.550)和死亡率(2.3%比 3.8%,p=1.000)两组间无差异。术后 1 个月,ABI 改善更明显的患者中,ABF 组在基线 ABI 较低的下肢(0.56 比 0.50,p=0.018)和较高的下肢(0.49 比 0.34,p=0.001)的比例明显高于 EVT 组,而两组间 Rutherford 分类的变化无显著差异(p=0.590)。术后 5 年,与 EVT 组相比,ABF 组的初始通畅率(89.4±4.3%比 74.8±4.3%,p=0.035)和生存率(86.9±4.5%比 66.2±7.5%,p=0.007)明显更高。然而,两组间次要通畅率(100.0%±0.0%比 93.5%±3.9%,p=0.160)和免于靶病变血运重建(TLR)率(89.3±4.3%比 77.3±7.3%,p=0.096)无显著差异。

结论

即使 EVT 技术最近有了进步,ABF 治疗 IAA 下段 CTO 的初始通畅率仍明显更高。然而,两组在术后 5 年的次要通畅率和免于 TLR 方面无差异。此外,在围手术期,两组在手术成功率、并发症、死亡率和 Rutherford 分类改善方面无差异,EVT 组的手术时间和住院时间明显更短。

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