血管在猪体内白三烯生物转化中的作用。
The role of blood vessels in the bioconversion of leukotrienes in the pig.
作者信息
Galton S A, Piper P J
出版信息
Br J Pharmacol. 1987 Mar;90(3):617-22. doi: 10.1111/j.1476-5381.1987.tb11213.x.
Abstract
Porcine pulmonary artery has the ability to convert leukotriene C4 (LTC4) to LTD4 and then to LTE4. In this vessel, there appears to be no further metabolism beyond LTE4. LTC4 (1 nM) is converted rapidly to LTD4, whereas the conversion of LTD4 to LTE4 is somewhat slower. The conversion of LTC4 to LTD4 is inhibited by the gamma-glutamyl transpeptidase inhibitor, serine-borate (45 mM). The conversion of LTD4 to LTE4 is inhibited by the aminopeptidase inhibitor, L-cysteine (10 mM). LTB4 did not appear to be metabolized by porcine pulmonary artery. These results suggest that the vessel wall may play a role in the early stages of leukotriene metabolism.
摘要
猪肺动脉具有将白三烯C4（LTC4）转化为白三烯D4（LTD4），进而转化为白三烯E4（LTE4）的能力。在这种血管中，LTE4似乎没有进一步的代谢。LTC4（1纳摩尔）能迅速转化为LTD4，而LTD4转化为LTE4的速度则稍慢一些。LTC4向LTD4的转化受到γ-谷氨酰转肽酶抑制剂丝氨酸-硼酸盐（45毫摩尔）的抑制。LTD4向LTE4的转化受到氨肽酶抑制剂L-半胱氨酸（10毫摩尔）的抑制。白三烯B4（LTB4）似乎未被猪肺动脉代谢。这些结果表明，血管壁可能在白三烯代谢的早期阶段发挥作用。
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