白三烯C4和D4对豚鼠离体心脏的作用。
The actions of leukotrienes C4 and D4 on guinea-pig isolated hearts.
作者信息
Letts L G, Piper P J
出版信息
Br J Pharmacol. 1982 May;76(1):169-76. doi: 10.1111/j.1476-5381.1982.tb09203.x.
Abstract
1 Infusions of leukotrienes C4 (LTC4) and LTD4 (5 min; 4 X 10-10-2 X 10-8 M) produced dose-dependent decreases in coronary flow in Langendorff preparations of guinea-pig isolated heats. 2 LTC 4 was more active than LTD4 and produced greater reduction in coronary flow 3 LTC4 and LTD4 also caused reduction in contractility in perfused hearts but not in isolated atria or driven ventricular strips. 4 There was a greater reduction in contractility to LTD4 compared with LTC4 at doses which produced approximately 50% reduction in coronary flow. 5 Indomethacin (1.4 X 10-5 M) inhibited the effects of LTC4 but only reduced the initial LTD4- induced effects. 6 The effects of FPL 55712 (3.8 X 10-6 M) were similar to those of indomethacin. 7 LTC4 and LTD4 may therefore contribute to the abnormalities of cardiac function that occur in immediate hypersensitivity reactions, particularly reduction in coronary flow.
摘要
- 白三烯C4（LTC4）和白三烯D4（LTD4）（5分钟；4×10⁻¹⁰ - 2×10⁻⁸M）的输注使豚鼠离体心脏Langendorff标本的冠状动脉血流量呈剂量依赖性减少。2. LTC4比LTD4更具活性，使冠状动脉血流量减少得更多。3. LTC4和LTD4还导致灌注心脏的收缩力降低，但对离体心房或驱动的心室条带没有影响。4. 在使冠状动脉血流量减少约50%的剂量下，与LTC4相比，LTD4导致的收缩力降低幅度更大。5. 吲哚美辛（1.4×10⁻⁵M）抑制LTC4的作用，但仅降低LTD4最初诱导的作用。6. FPL 55712（3.8×10⁻⁶M）的作用与吲哚美辛相似。7. 因此，LTC4和LTD4可能导致速发型超敏反应中出现的心脏功能异常，尤其是冠状动脉血流量减少。
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