Birkeness Lauren B, Banerjee Snigdha, Quadir Mohiuddin, Banerjee Sushanta K
Cancer Research Unit, Research Division, VA Medical Center, 4801 Linwood Blvd, Kansas City, MO, 64128, USA.
Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, 66106, USA.
J Cell Commun Signal. 2023 Mar;17(1):35-45. doi: 10.1007/s12079-022-00682-2. Epub 2022 Jun 8.
The Cellular communication network (CCN) family of growth regulatory factors comprises six secreted matricellular proteins that promote signal transduction through cell-cell or cell-matrix interaction. The diversity of functionality between each protein is specific to the many aspects of healthy and cancer biology. For example, CCN family proteins modulate cell adhesion, proliferation, migration, invasiveness, apoptosis, and survival. In addition, the expression of each protein regulates many biological and pathobiological processes within its microenvironment to regulate angiogenesis, inflammatory response, chondrogenesis, fibrosis, and mitochondrial integrity. The collective range of CCN operation remains fully comprehended; however, understanding each protein's microenvironment may draw more conclusions about the abundance of interactions and signaling cascades occurring within such issues. This review observes and distinguishes the various roles a CCN protein may execute within distinct tumor microenvironments and the biological associations among them. Finally. We also review how CCN-family proteins can be used in nano-based therapeutic implications.
细胞通讯网络（CCN）家族的生长调节因子由六种分泌型基质细胞蛋白组成，这些蛋白通过细胞间或细胞与基质的相互作用促进信号转导。每种蛋白之间功能的多样性特定于健康生物学和癌症生物学的许多方面。例如，CCN家族蛋白可调节细胞黏附、增殖、迁移、侵袭性、凋亡和存活。此外，每种蛋白的表达调节其微环境内的许多生物学和病理生物学过程，以调节血管生成、炎症反应、软骨形成、纤维化和线粒体完整性。CCN的整体作用范围仍有待充分理解；然而，了解每种蛋白的微环境可能会得出更多关于此类问题中发生的大量相互作用和信号级联的结论。本综述观察并区分了CCN蛋白在不同肿瘤微环境中可能发挥的各种作用以及它们之间的生物学关联。最后，我们还综述了CCN家族蛋白如何用于基于纳米的治疗应用。
