College of Chemistry and Materials Science, Inner Mongolia Minzu University, Tongliao 028000, China.
Inner Mongolia Key Laboratory of Carbon Nanomaterials, Nano Innovation Institute (NII), Inner Mongolia Minzu University, Tongliao 028000, China.
J Org Chem. 2022 Jun 17;87(12):8142-8150. doi: 10.1021/acs.joc.2c00852. Epub 2022 Jun 8.
The rhodium(III)-catalyzed C-H activation followed by intramolecular annulation reactions between arylhydrazines and iodonium ylides under suitable conditions has been described. Tetrahydrocarbazol-4-ones are readily achieved with moderate to excellent yields. The synthetic protocol features a wide range of substrates with high functional group tolerance. The gram-scale reaction and derivatization of the product demonstrate the synthetic practicality and utilization of this method.
铑(III)催化的 C-H 活化，随后在适当的条件下，芳基腙与碘代𬭩叶立德之间进行分子内环化反应，已经得到了描述。四氢咔唑-4-酮可以很容易地以中等至优秀的收率得到。该合成方案具有广泛的底物范围，对官能团具有高耐受性。克级反应和产物的衍生化证明了该方法的合成实用性和可利用性。
