68Ga-FAPI PET/CT 显示的结肠印戒细胞癌肾周浸润

Perirenal Infiltration of Signet Ring Cell Colon Carcinoma Shown by 68Ga-FAPI PET/CT.

机构信息

From the Departments of Nuclear Medicine.

Pathology, Gazi Yaşargil Training and Research Hospital, University of Health Sciences, Diyarbakır, Turkey.

出版信息

Clin Nucl Med. 2022 Jul 1;47(7):e509-e512. doi: 10.1097/RLU.0000000000004166. Epub 2022 Apr 5.

DOI:10.1097/RLU.0000000000004166

PMID:35675142

Abstract

A soft tissue lesion surrounding the left kidney was detected in 18F-FDG PET/CT performed with suspicion of recurrence in a patient who was operated for descending colon cancer and showed mild FDG uptake. Intense fibroblast activation protein-specific inhibitor (FAPI) uptake in the perirenal soft tissue was observed in 68Ga-FAPI-04 PET/CT. Tru-cut biopsy of the left perirenal lesion revealed signet ring cell colon carcinoma metastasis. This case demonstrated that 68Ga-FAPI-04 PET/CT could be a promising radiopharmaceutical for the evaluation of signet ring cell colon carcinomas.

摘要

在对疑似降结肠癌复发的患者进行 18F-FDG PET/CT 检查时，发现左肾周围软组织有病变，该患者曾接受过手术治疗，FDG 摄取轻度升高。在 68Ga-FAPI-04 PET/CT 中观察到左肾周软组织有强烈的成纤维细胞激活蛋白特异性抑制剂（FAPI）摄取。左肾周病变的 tru-cut 活检显示印戒细胞结肠癌转移。本病例表明，68Ga-FAPI-04 PET/CT 可能是评估印戒细胞结肠癌的一种有前途的放射性药物。