Department of Environmental Medicine and Population Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Department of Hematology, Kobe City Hospital Organization, Kobe City Medical Center General Hospital, Kobe, Japan.
J Nutr. 2022 Aug 9;152(8):1895-1906. doi: 10.1093/jn/nxac122.
Meat, fish, and fatty acid intakes have been reported to be associated with non-Hodgkin lymphoma (NHL), although results have been inconclusive. We hypothesized that red meat and SFA intakes increase NHL risk, and fish and PUFA intakes decrease NHL risk.
We investigated the association between NHL incidence and meat, fish, and various fatty acid type intakes using the Japan Public Health Center-based Prospective Study.
The current cohort study included 93,366 participants aged 45-74 y who were eligible for analysis; they were followed up until December 2012. Participants answered an FFQ between 1995 and 1999. We analyzed the effects of meat, fish, total fatty acid, SFA, and PUFA intakes on NHL incidence using the Cox proportional hazard model.
The median age was 57 y (IQR: 51-63 y), and 46.5% of the participants were men. Participants were followed up for 1,345,001 person-years, and 230 patients with NHL were identified. Total fatty acid and SFA intakes were associated with an increased incidence of NHL, with an adjusted HR of 1.56 (95% CI: 1.04, 2.34 highest compared with lowest quartile; P-trend = 0.062), and 1.63 (95% CI: 1.11, 2.41; P-trend = 0.074), respectively. In subtype analysis, total fatty acid and SFA intakes were also associated with increased incidence of follicular lymphoma but were not significantly associated with diffuse large B-cell lymphoma. Conversely, total meat, processed meat, unprocessed meat, red meat, poultry, fish, MUFA, PUFA, n-3 (ω-3) PUFA, and n-6 (ω-6) PUFA intakes were not significantly associated with the incidence of NHL or its subtypes.
Total fatty acid and SFA intakes were associated with increased incidence of NHL in the Japanese adult population. Further large-scale studies are warranted to test whether fatty acid intakes affect the development of NHL.
肉类、鱼类和脂肪酸的摄入量与非霍奇金淋巴瘤（NHL）有关，尽管结果尚无定论。我们假设，红肉和饱和脂肪酸（SFA）的摄入量会增加 NHL 的风险，而鱼类和多不饱和脂肪酸（PUFA）的摄入量则会降低 NHL 的风险。
我们使用日本公共卫生中心前瞻性研究调查了 NHL 发病率与肉类、鱼类和各种脂肪酸类型摄入量之间的关系。
本队列研究包括 93366 名年龄在 45-74 岁之间、符合分析条件的参与者；随访至 2012 年 12 月。参与者于 1995 年至 1999 年之间回答了一份食物频率问卷。我们使用 Cox 比例风险模型分析了肉类、鱼类、总脂肪酸、SFA 和 PUFA 摄入量对 NHL 发病率的影响。
中位年龄为 57 岁（IQR：51-63 岁），46.5%的参与者为男性。参与者的随访时间为 1345001 人年，共发现 230 例 NHL 患者。总脂肪酸和 SFA 的摄入量与 NHL 的发病率增加相关，最高四分位数与最低四分位数相比，调整后的 HR 分别为 1.56（95%CI：1.04，2.34；P-trend=0.062）和 1.63（95%CI：1.11，2.41；P-trend=0.074）。在亚型分析中，总脂肪酸和 SFA 的摄入量也与滤泡性淋巴瘤发病率的增加相关，但与弥漫性大 B 细胞淋巴瘤无显著相关性。相反，总肉、加工肉、未加工肉、红肉、家禽、鱼、单不饱和脂肪酸（MUFA）、PUFA、n-3（ω-3）PUFA 和 n-6（ω-6）PUFA 的摄入量与 NHL 或其亚型的发病率无显著相关性。
在日本成年人群中，总脂肪酸和 SFA 的摄入量与 NHL 发病率的增加有关。需要进一步进行大规模研究，以验证脂肪酸的摄入量是否会影响 NHL 的发生。
