Institute of Continuing Medical Education of Ioannina, Ioannina, Greece.
Clin Infect Dis. 2022 Nov 14;75(10):1845-1847. doi: 10.1093/cid/ciac463.
An inadequacy in sanitizing processes in a biopharmaceutical plant in Lanzhou, China, during July and August 2019, led to the aerosolization of Brucella that was subsequently spread through wind to nearby settlements and academic institutes, resulting in >10 000 human brucellosis cases, as of November 2020. The leak, possibly the largest laboratory accident in the history of infectious diseases, underlines the particular characteristics of Brucella that have made the pathogen a historical entity in biodefense research and a major cause of laboratory-associated infections. It further underlines the need for enhanced vigilance and strict regulatory interventions in similar facilities.
2019 年 7 月至 8 月，中国兰州一家生物制药厂的消毒过程存在缺陷，导致布鲁氏菌气溶胶化，随后通过风传播到附近的定居点和学术机构，截至 2020 年 11 月，导致超过 10000 例人类布鲁氏菌病病例。此次泄漏事件可能是传染病史上最大的实验室事故，突显了布鲁氏菌的特殊特征，使其成为生物防御研究中的历史实体，也是实验室相关感染的主要原因。它进一步强调了在类似设施中加强警惕和严格监管干预的必要性。
