长寿秘诀：多能性超级力量。

Longevity secret: A pluripotent superpower.

机构信息

State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China; Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China; Aging Translational Medicine Center, International Center for Aging and Cancer, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.

出版信息

Cell Metab. 2022 Jun 7;34(6):803-804. doi: 10.1016/j.cmet.2022.05.001.

DOI:10.1016/j.cmet.2022.05.001

PMID:35675798

Abstract

Mammalian lifespans are dramatically diverse. Identifying the molecular signatures and underlying mechanism of longevity is of keen interest. Using comparative transcriptomics, Lu et al. (2022) showed that genes associated with maximum lifespan are regulated by circadian and pluripotency networks, which shed light on natural strategies for controlling lifespan.

摘要

哺乳动物的寿命差异巨大。确定长寿的分子特征和潜在机制是人们非常感兴趣的。Lu 等人（2022 年）使用比较转录组学表明，与最大寿命相关的基因受昼夜节律和多能性网络的调控，这为控制寿命的自然策略提供了线索。