O'Byrne K T, Eltringham L, Summerlee A J
Brain Res. 1987 Mar 3;405(1):80-3. doi: 10.1016/0006-8993(87)90991-7.
The effects of centrally administered porcine relaxin on the milk-ejection reflex were studied in anaesthetized, lactating rats. Injection of relaxin into either the lateral ventricles (10-1000 ng) or third ventricle (500 ng) of the brain significantly inhibited suckling-induced reflex milk-ejection. Following injection of relaxin into the third ventricle, the onset of inhibition was immediate and more profound compared to injection into the lateral ventricle, after which there was a delay to the onset of inhibition. Relaxin was without effect when injected into the fourth ventricle or cisterna magna, thus suggesting that the site of action was within the diencephalon and the mesencephalon. Because these effects were reversed by naloxone, the central inhibitory action of relaxin appears to be mediated through endogenous opioid peptides.
在麻醉的泌乳大鼠中研究了脑室内注射猪松弛素对排乳反射的影响。向大鼠脑侧脑室（10 - 1000 ng）或第三脑室（500 ng）注射松弛素，可显著抑制哺乳诱导的反射性排乳。向第三脑室注射松弛素后，抑制作用立即出现且比向侧脑室注射时更明显，向侧脑室注射后抑制作用出现有延迟。向第四脑室或小脑延髓池注射松弛素则无作用，因此提示作用部位在间脑和中脑。由于这些作用可被纳洛酮逆转，松弛素的中枢抑制作用似乎是通过内源性阿片肽介导的。
